Knowledge and attitude towards identification of systemic inflammatory response syndrome (SIRS) and sepsis among emergency personnel in tertiary teaching hospital

Rahman, Nurul ‘Inayati Abdul; Chong, Mei Chan; Zakaria, Mohd Idzwan; Jaafar, Mohd Johar

doi:10.1016/j.auec.2018.11.002

Cited by 18 publications

(35 citation statements)

References 25 publications

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“…Our study also found that residents had more knowledge regarding sepsis than the consultants. Similar results were reported by a study conducted in Malaysia 12 This could be because younger respondents were mainly residents who may have studied sepsis more recently, had more frequent encounters with septic patients due to their long hours of training, as well as differences in curriculum.…”

Section: Discussionsupporting

confidence: 86%

“…The second most effective method for diagnosing sepsis was hemodynamic monitoring, similar to previous study results. 7 , 12 Although bacterial cultures are the most reliable method to diagnose infections, it hinders the early detection and treatment. Several studies have shown that early detection and treatment with antibiotics can reduce sepsis-related mortality.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge and perception of Sepsis among Doctors in Karachi Pakistan

Ahmed

Abbasi²,

Herekar³

et al. 2021

Pak J Med Sci

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Objectives: To assess knowledge and perception among Pakistani physicians towards sepsis. Methods: This cross-sectional study was conducted in Indus Hospital and Health Networks from September 2020 to March 2021. The International Sepsis Survey questionnaire was adapted, and its link was sent to trainee physicians as well as specialists, and consultants practicing in various hospitals via social media. Knowledge and perception were scored and 50% was considered the cut-off score for adequacy. Data was analyzed using SPSS version 26. Results: Analysis was done on 222 respondents who completed the survey. 37.9% of the participants had adequate knowledge. Knowledge regarding sepsis was significantly associated with specialty, ICU/CCU/HDU, and work experience (P-value <0.0001). More recent trainee physicians and those with more experience in critical care areas demonstrated better knowledge. Over 2/3rd of the respondents strongly agreed that sepsis remains one of the unmet needs in critical care today. Conclusion: A common belief exists that sepsis remains a challenge to treat among doctors. Moreover, there is consensus that it is the most frequently miss diagnosed condition in critical care and a dire need exists for its early diagnosis. Additionally, prompt management of presumed sepsis is imperative to improve outcomes. doi: https://doi.org/10.12669/pjms.38.ICON-2022.5775 How to cite this:Ahmed F, Abbasi L, Herekar F, Jiwani A, Patel MJ. Knowledge and perception of Sepsis among Doctors in Karachi Pakistan. Pak J Med Sci. 2022;38(2):380-386. doi: https://doi.org/10.12669/pjms.38.ICON-2022.5775 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Knowledge and perception of Sepsis among Doctors in Karachi Pakistan

Ahmed

Abbasi²,

Herekar³

et al. 2021

Pak J Med Sci

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“…Dysregulation of miRNAs have attracting increasing attention for their critical roles in the pathogenesis of various human diseases, including inflammatory diseases such as SIRS [22]. Sepsis is considered a SIRS caused by infection, and the understanding about the immunopathology of SIRS and sepsis is important for the development of novel diagnostic and therapeutic approaches [23]. Currently, some aberrantly expressed miRNAs have been identified in sepsis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of miR-103 in Patients with Sepsis and Noninfectious SIRS and Its Regulatory Role in LPS-Induced Inflammatory Response by Targeting TLR4

Yang

Zhao

Sun

2020

International Journal of Genomics

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Background. Sepsis is a life-threatening condition and a systemic inflammatory response syndrome (SIRS) driven by infection. This study aimed at investigating the expression of microRNA-103 (miR-103) in sepsis patients, evaluating its diagnostic value, and exploring the regulatory effect of miR-103 on LPS-induced inflammation in monocytes. Methods. Expression of miR-103 was measured using quantitative real-time PCR. A receiver operating characteristics curve was plotted to evaluate the diagnostic vale of miR-103. Serum and cell supernatant levels of proinflammatory cytokines were analyzed using ELISA. The interaction between miR-103 and Toll-like receptors 4 (TLR4) was analyzed using luciferase reporter assay. The effect of miR-103 on inflammation was examined in LPS-treated monocytes. Results. Serum expression of miR-103 was decreased in noninfectious SIRS and sepsis patients compared with healthy controls, and the lowest expression value was observed in sepsis patients (all P<0.05). Serum levels of miR-103 have considerable diagnostic accuracy in distinguishing sepsis patients from SIRS patients and healthy controls. A negative correlation was found between miR-103 and inflammatory responses in sepsis patients. TLR4 was demonstrated to be a direct target of miR-103 and was negatively regulated by miR-103 in monocytes. The promoted inflammatory responses by LPS in monocytes were reversed by the overexpression of miR-103. Conclusion. All the data revealed that serum decreased miR-103 in sepsis patients serves as a promising noninvasive diagnostic biomarker and may be involved in the pathogenesis of sepsis by regulating inflammatory responses via targeting TLR4.

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“…8 Abdul Rahman and colleagues identi ed de ciencies among nurses and physicians in the ED. 12 However, sepsis-speci c training is associated with signi cant improvement in such de ciencies. 18 This study's strengths include the number of participants, the participation rate, the combined assessment of nurses, physicians and paramedics and the breadth departments of adult medicine assessed.…”

Section: Discussionmentioning

confidence: 99%

Sepsis Awareness at the University Hospital Level: A Survey-Based Cross-Sectional Study

Regina

Pogam

Niemi

et al. 2021

Preprint

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Background: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improved outcomes. In 2019, the Lausanne University Hospital (LUH) launched a quality of care project aiming to improve sepsis management. As part of this effort, we aimed to assess sepsis awareness among nurses and physicians of the LUH and among the local paramedics. Methods: We conducted a survey on nurses and physicians at our institution and local paramedics between January and October 2020 representing over 1,000 professionals distributed over all hospital departments. The survey assessed professionals’ knowledge of sepsis epidemiology, definition, recognition and initial evaluation (nurses and paramedics) or sepsis epidemiology, diagnosis, and management (physicians). Pediatrics and the neonatal unit were excluded. Results: A total of 1,116 of 1,216 contacted persons among the 4417 targeted population participated and completed the survey (participation rate 91.8%). This included 619 of 2,463 (25.1%) of hospital nurses, 348 of 1,664 (20.9 %) of physicians and 149 of 290 (51.4%) of canton paramedics. Our nurse and physician sample was slightly imbalanced for sex and age. Thirteen percent of participants (28.4% of physicians, 5.9% of nurses, 6.8% of paramedics) correctly identified the Sepsis-3 consensus definition. Similarly, 48.6% of physicians and 10.0% of nurses identified the SOFA (sequential organ failure assessment) score as a sepsis defining score for infected patients. Furthermore, 24% of participants identified the Quick Sepsis-related Organ Failure Assessment (qSOFA) score as a predictor of increased mortality; 6% identified correctly the components of the score. For a patient with suspected sepsis, 96.1%, 91.6% and 75.8% of physicians respectively identified blood cultures, broad-spectrum antibiotics and fluid resuscitation as required interventions; 76.4% and 18.2% of physicians requested these initial measures within 1 and 3 hours, respectively. For physicians, recent training correlated with awareness regarding definitions, SOFA score and qSOFA score use and components: ORs (95%CI) 2.2 (1.4-3.6), 4.3 (2.7-6.7), 3.4 (2.2-5.2), and 2.6 (1.5-4.6), respectively).Conclusions: We identify a deficit of awareness among physicians, nurses and paramedics at LUH correlating with a lack of sepsis-specific training. Enhanced sepsis-specific educational efforts could significantly improve early identification and treatment of affected patients.

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Knowledge and attitude towards identification of systemic inflammatory response syndrome (SIRS) and sepsis among emergency personnel in tertiary teaching hospital

Cited by 18 publications

References 25 publications

Knowledge and perception of Sepsis among Doctors in Karachi Pakistan

Knowledge and perception of Sepsis among Doctors in Karachi Pakistan

Diagnostic Value of miR-103 in Patients with Sepsis and Noninfectious SIRS and Its Regulatory Role in LPS-Induced Inflammatory Response by Targeting TLR4

Sepsis Awareness at the University Hospital Level: A Survey-Based Cross-Sectional Study

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