This article argues that the medical discourse of Machiavelli's “Mandragola” is profoundly important both for understanding the play and for revisiting its author's philosophical and political writings. I show that discussions in “Mandragola” of doctors, medicine, eating, and elimination ultimately break down the traditional paradigm that opposes truth, nourishment, and healing to deception, problematic food, and illness. The play's extended discourse around medicine undermines the ideal of the physician who heals the state and the pharmakon of words that heal the soul (in Plato, Livy, Saint Augustine, and Machiavelli's “Discorsi”), questioning in turn notions of knowledge and truth.