Cervical cancer is caused by human papillomavirus (HPV) but it can be reduced by HPV infection. The aimed of this study was to explore perception and knowledge about HPV, cervical cancer and HPV vaccine in Ciranjang West Java, Indonesia. This was a cross sectional study of 90 adult female in Ciranjang, West Java, Indonesia. A 31 item self-report questionnaire was completed in this study. The reliability of this tool was assessed using Cronbach’s alpa (0.86) and the Kaiser-Meyer-Olkin value was 0.704. A total of 90 questionnaire were distributed, completed and analyzed. Only 42 (46.7%), 69 (76.7%) and 69 (76.7%) of adult female had ever heard of HPV infection, cervical cancer and HPV vaccine respectively. Only 13 (14.4%) knew that HPV can cause herpes and 28 (31.3%) knew that HPV can cause genital warts. Of the 44 adult female knew that there is a vaccine being developed to prevent HPV infection. Generally, the perception, knowledge and attitude about HPV among adult female were low. There is a need for health promotion to improve knowledge, perception and HPV vaccine