Background: Novel coronavirus is a global pandemic and killed many individuals, including health care professionals. It caused stress on the health care system of all countries. Presently, studies are emerging regarding the COVID-19 pandemic in different aspects. However, a few have explored militating factors that affecting the practice of preventive measures for the COVID-19. As such, the study aimed to fill these research gaps in the study setting.Methods: A semi-structured interview guide used to conduct this phenomenological study among 16 key informants. Key informants recruited by the purposive sampling method. The data analyzed inductively by using a thematic content analysis approach in NVivo 12 Pro software. Results: In this study, six main themes identified with the sub-themes. Overview of COVID-19 pandemic, consequences (with the two sub-theme), perceived practice (with four sub-theme), perceived militating factors (with four sub-theme), newfangled activities (with three sub-theme), and suggestion for improvement (with seven sub-theme) were the major themes. The participants perceived the influence of shortage of personal protective equipment and solutions for hand hygiene, negligence and ignorance, inadequate infrastructure, lack of training, and lack of attention and recognition for the staff on the practice of preventive measures. Conclusions: Conclusions: This study showed that there were gaps in the practice of preventive measures for the COVID-19 among health professionals in the health care system. Community influences, health care provider related factors, institutional factors, and lack of communication and support affect the practice. Hence, attention should give to fulfill the necessary supplies in the health facilities, improve the infrastructures, and equip health professionals by providing capacity-building activities. Besides, health care professionals must recognize, and credit should consider.