Topical creams used to treat and prevent melasma and freckles contain corticosteroids, hydroquinone, mercury, and retinoic to lighten skin color. Misuse of these products and the rate of adverse effects have increased greatly in recent years. This study aims to assess the misuse of topical cream to prevent and treat melasma and freckles among working women in northeast Thailand. Our population consisted of 1,143 working women in the region aged 30-59 years old. The respondents were recruited from four provinces eight districts using a structured questionnaire distributed via a multi-stage random sampling method. Descriptive statistics and logistic regression were used to represent and analyze the data. Eight hundred sixty-two (75.42%) of the respondents were users, and 105 (12.18%) had misused the products. The prevalence of misuse of products containing mercury, steroids, hydroquinone, retinoic acid, and mercury plus retinoic acid was 43.8%, 11.43%, 15.24%, 12.38%, and 17.15%, respectively. Factors associated with misuse of this product were age 30-44 years, education level less than a bachelor’s degree, working as a housekeeper or freelancer, presence of melasma and freckles, average monthly income ≤ 15,000 THB and low levels of knowledge and health literacy. Misuse of medication to treat pigmentary disorders is a growing public health concern. Social media and nonprofit campaigns should be implemented to create awareness of these products' misuse and adverse effects.