Objectives:To analyze the prevalence of work-related musculoskeletal disorders (WR-MSD) among the IT professionals from Bangalore South and to detect the correlation between musculoskeletal disorders and age, gender, and working hours a person puts in. Materials and Method: A population of 563 IT Professionals from various multinational companies in Bangalore South was sent a self-assessed Nordic quiz to find the prevalence of MSD, which includes pain in different body parts like the neck and shoulders lower back, etc. To examine the associations between different variables, correlation analysis was conducted. The duration of the study was six weeks. Results: A population of 563 participants was analyzed for the study. Out of those participants, (34.2%) reported WR-MSD affecting the neck, upper back (35.5%), and lower back (37.3%) during the past 12 months, including overlapping between the two sites or even all the three sites making cervical and lumbar the most common sites of pain. Office work pressure, meeting project deadlines, social media, lack of breaks, and poor understanding of ergonomics were significantly correlated with WR-MSD. Analysis also revealed that younger age groups, females, and people working between 9-10 hours are at increased risk of developing musculoskeletal disorders, and have difficulties in doing ADL. Conclusion: Age, gender, and the number of working hours play a major role in the prevalence of WR-MSD in IT professionals in Bangalore South. Based on findings in the study, it is suggested that prevention and treatment efforts be directed towards avoidance of WR-MSD and focus on cognitive work factors such as the harmful way of work and biomechanical risk factors. Novelty: The novelty of this study was to find out the prevalence and the correlation between the age, gender, and working hours which has not been done before, and to spread the awareness to the said population on how to avoid the physical strain and reach out for help whenever required to improve productivity.