Knowledge, attitude, and practice towards bacterial multidrug-resistance and structural equation modeling analysis among intensive care unit nurses and physicians

Abstract

Background The intensive care unit (ICU) is a department with a high risk of MDR bacteria, and ICU nurses and physicians play critical roles in bacterial multidrug resistance (MDR) prevention. Objectives To explore the knowledge, attitudes, and practice (KAP) towards bacterial MDR among ICU nurses and physicians. Methods A self-designed questionnaire was administered to collect data. Structural equation modeling (SEM) was applied to assess the associations among study variables. Results A total of 369 questionnaires were collected; 43 questionnaires were excluded due to self-contradictory on the trap question or the obviously repeated pattern. Finally, 326 (88.35%) valid questionnaires were included in the analysis. The knowledge, attitudes, and practice were 13.57 ± 1.69 (90.47%, possible range: 0–15), 38.75 ± 2.23 (96.88%, possible range: 8–40), and 47.40 ± 3.59 (94.80%, possible range: 10–50). The SEM showed that knowledge had a direct effect on attitude with a direct effect value of 0.61 (P < 0.001) and a direct negative effect on practice with a direct effect value of -0.30 (P = 0.009). The direct effect of attitude on practice was 0.89 (P < 0.001); the indirect effect of knowledge through attitude on practice was 0.52 (P < 0.001). Job satisfaction had a direct effect on attitude and practice, with an effect value of 0.52 (P = 0.030) and 0.75 (P = 0.040). Being a physician (OR = 0.354, 95%CI: 0.159–0.790, P = 0.011), 5–9.9 years of practice (OR = 4.534, 95%CI: 1.878–8.721, P < 0.001), and ≥ 10 years of practice (OR = 3.369, 95%CI: 1.301–8.721, P = 0.012) were independently associated with good knowledge. The attitude scores (OR = 1.499, 95%CI: 1.227–1.830, P < 0.001), male gender (OR = 0.390, 95%CI: 0.175–0.870, P = 0.022), and 5–9.9 years of experience (OR = 0.373, 95%CI: 0.177–0.787, P = 0.010) were independently associated with proactive practice. Conclusion Nurses and physicians in the ICU showed good knowledge, positive attitudes, and proactive practice toward bacterial MDR. Nurses and physicians’ knowledge had a direct effect on their attitude, while attitude might directly influence the practice and also play a mediating role between knowledge and practice. Job satisfaction might directly support the positive attitude and practice toward bacterial MDR.