Knowledge, Attitudes, and Practices Concerning Malaria in Pregnancy: Results from a Qualitative Study in Madang, Papua New Guinea

Andrew, Erin; Pell, Christopher; Angwin, Angeline; Auwun, Alma; Daniels, Jena; Müeller, Ivo; Phuanukoonnon, Suparat; Pool, Robert

doi:10.1371/journal.pone.0119077

Cited by 25 publications

(26 citation statements)

References 42 publications

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“…Results of this study showed that Community Health Workers were the main source of household’s information about malaria and IRS. This finding is consistent with findings in other studies from different malaria endemic regions around the world which indicates that Community Health Workers are frequently in contact with people [ 21 , 25 , 26 ]. This is in contrast to findings from a recent study conducted in Saudi Arabia, India and Uganda that reported the social media as the primary source of malaria information [ 20 , 27 , 28 ].…”

Section: Discussionsupporting

confidence: 93%

Household knowledge and practices concerning malaria and indoor residual spraying in an endemic area earmarked for malaria elimination in Iran

et al. 2017

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BackgroundIndoor residual spraying of insecticide (IRS) is a key intervention for reducing the burden of malaria infection. Effectiveness and success of this strategy are to a considerable extent dependent on knowledge and practice of the target community regarding the IRS. Iran has entered the malaria elimination phase, and IRS has been considered as the main strategy for malaria vector control. Therefore, this study was conducted to determine the household knowledge and practices about malaria and IRS in Bashagard County, one of the malaria-endemic areas in the southeast of Iran.MethodsA community-based cross-sectional survey was conducted among 420 households in Bashagard County. The participants who were selected using a two-stage randomized cluster sampling procedure were subjected to a tested structured questionnaire. During the survey, direct observations were made concerning the use of IRS as well as housing conditions. The data were coded and analysed using SPSS version 19.ResultsKnowledge levels about malaria as a disease and the mosquito as its vector were high and of equal magnitude (85.5% and 85.4%, respectively), while knowledge levels of IRS were even higher (91.6%). The main source of households’ information about malaria and IRS was primarily community health workers (73.3%). Despite positive perceptions towards IRS only 26.7% of respondents had sprayed their houses which is lower than the WHO targeted coverage of 80%. Respiratory disorders and headache (33.3%), food contamination (24.9%), discolouring of inner house walls (17.7%), difficulty in furniture’s movement (13.8%), and unpleasant odour (10.4%) were the main reasons for IRS refusal.ConclusionThere is a discrepancy between knowledge about symptoms and the transmission route of malaria and control practices related to IRS use. Therefore, IRS campaigns accompanied with education for behaviour change should be considered to ensure householders’ participation and cooperation in the IRS programme. Moreover, continuous evaluation and monitoring of IRS as well as conducting more surveys on knowledge, attitude, and practices are recommended to improve malaria control measures and to identify indicators for effective, successful, and sustainable malaria elimination programme.

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Section: Discussionsupporting

confidence: 93%

Household knowledge and practices concerning malaria and indoor residual spraying in an endemic area earmarked for malaria elimination in Iran

et al. 2017

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“…T-type calcium channels can be divided into three subtypes: α1G (Cav3.1), α1H (Cav3.2), and α1I(Cav3.3) [16]. Andrew et al reported that human uterine smooth muscle tissue primarily expresses α1G (Cav3.1) while α1I (Cav3.3) was barely detectable [17]. Our results show that Cav3.1 and Cav3.2 expression was significantly increased in women experiencing preterm labor, indicating that Cav3.1 and Cav3.2 expression is strongly associated with preterm labor.…”

Section: Discussionmentioning

confidence: 99%

TRPC3 Overexpression Promotes the Progression of Inflammation-Induced Preterm Labor and Inhibits T Cell Activation

Chen¹,

Dongming²,

Chen³

et al. 2018

Cell Physiol Biochem

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Background/Aims: To detect the expression of the TRPC3 channel protein in the tissues of women experiencing preterm labor and investigate its interaction with T lymphocytes, providing a theoretical basis for the clinical prevention of threatened preterm labor and the development of drug-targeted therapy. Methods: Forty-seven women experiencing preterm labor and 47 women experiencing normal full-term labor were included in this study. All included women underwent delivery via cesarean section; uterine samples were obtained at delivery. The expression of TRPC3 in uterine tissue was detected by immunohistochemistry, real-time quantitative reverse transcription-PCR, and western blot assay. Activation of T lymphocytes in peripheral blood and uterine tissue were detected by flow cytometry. A TRPC3^-/- mouse model of inflammation-induced preterm labor was established; expression of TRPC3, Cav3.1, and Cav3.2 were analyzed in mouse uterine tissue. Activation of T lymphocytes in female mouse and human peripheral blood samples was determined using flow cytometry. Results: In women experiencing preterm labor, expression of TRPC3 and the Cav3.1 and Cav3.2 proteins was significantly increased; in addition, the percentage of CD3⁺, CD4⁺, and CD8⁺ T cells in peripheral blood was significantly decreased. TRPC3 knockout significantly delayed the occurrence of preterm labor in mice. The muscle tension of ex vivo uterine strips was lower, Cav3.1 and Cav3.2 protein expression was lower, and the percentage of CD8⁺ T lymphocytes was significantly increased in wild-type mice subjected to an inflammation-induced preterm labor than in wild-type mice experiencing normal full-term labor. Conclusion: TRPC3 is closely related to the initiation of labor. TRPC3 relies on Cav3.1 and Cav3.2 proteins to inhibit inflammation-induced preterm labor by inhibiting the activation of T cells, in particular CD8⁺ T lymphocytes.

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“…12,15,26 Another study conducted in Papua New Guinea showed that the availability of ITNs and perceived discomfort of sleeping under the nets were important determinants of its usage. 27 There were also reports that ITNs were sold at high prices to people in some of the health care facilities. In another instance, health care staff was seen to hoard the ITNs for personal use.…”

Section: Discussionmentioning

confidence: 99%

Barriers to effective uptake of malaria prevention interventions in Ibadan, South West Nigeria: a qualitative study

Oladimeji

Tsoka-Gwegweni

Gengiah

et al. 2018

Int J Community Med Public Health

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Background: Although control measures have achieved considerable success, malaria is still a major public health problem in Nigeria and sub-Saharan Africa. The malaria burden is more among vulnerable groups like pregnant women and under-five aged children. This study explored barriers affecting uptake of current malaria prevention interventions in Ibadan, Southwest Nigeria.Methods: The study was conducted using qualitative research methods between May and August 2016 among community residents in Ibadan, Oyo state-Nigeria. Six focus group discussions (FGDs) and 16 in-depth interviews (IDI) were conducted with community members who were purposively selected and consented to participate in the study. The participants were grouped into six homogenous focus groups which included; pregnant women, mothers of under-five children, husbands, fathers, civil society members, and health staff such as hospital manager, nurses, pharmacist, medicine vendors, doctors, state program staff and national program staff. Data were transcribed, manually coded and analysed using content and thematic method. The Biomedical Research Ethics Committee (BREC), University of KwaZulu-Natal, South Africa and Oyo state Ministry of Health Ethics Committee, Nigeria both approved the study.Results: Knowledge on malaria causality and symptoms, prevention strategies, beliefs, fear of side effects from current malaria preventive measures, corruption and difficulty in obtaining nets, and poor environmental hygiene were some of the themes which emerged as barriers to the effective uptake of malaria prevention intervention.Conclusions: Strategies at the community level are urgently needed to address and improve within socio-cultural context uptake of current malaria prevention interventions.

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Knowledge, Attitudes, and Practices Concerning Malaria in Pregnancy: Results from a Qualitative Study in Madang, Papua New Guinea

Cited by 25 publications

References 42 publications

Household knowledge and practices concerning malaria and indoor residual spraying in an endemic area earmarked for malaria elimination in Iran

Household knowledge and practices concerning malaria and indoor residual spraying in an endemic area earmarked for malaria elimination in Iran

TRPC3 Overexpression Promotes the Progression of Inflammation-Induced Preterm Labor and Inhibits T Cell Activation

Barriers to effective uptake of malaria prevention interventions in Ibadan, South West Nigeria: a qualitative study

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