Research on the attitude of diabetes retinopathy's (DR) patients towards teleophthalmology as a branch of telemedicine has not been examined in developing countries. This article examines the receptiveness attitude of the patients with DR towards the use of teleophthalmology using 400 questionnaires to examine patients in Calabar DR screening center in Cross River State, Nigeria. The hypotheses were tested using multiple indicators multiple causes (MIMIC) as a special case of the structural equation modeling (SEM). The findings in this study indicated high cost and excess time negatively affects patient attitude, information, knowledge, and experience significantly and positively predict patients attitude towards teleophthalmology. Furthermore, the result of the paper shows that convenience and knowledge for 35.7 percent of the receptiveness of patients towards teleophthalmology. This study contributes by identifying that among other factors positive factors to enhance patient's receptive attitude to being diagnosis with diabetes retinopathy through telemedicine.