Knowledge of ancient Hindu surgeons on Hirschsprung disease: evidence from Sushruta Samhita of circa 1200-600 bc

Adult outcomes after surgery for Hirschsprung’s disease: Evaluation of bowel function and quality of life

“…Megacolon had been described before Dr Hirschsprung's publication and some speculate that even Hindu surgeons about 2,000 BC had some knowledge of the disease. 2 The doctoral thesis "Megacolon in the newborn", which was defended 70 years ago at Karolinska Institutet by Theodor Ehrenpreis, was one milestone in the history of HSCR. Ehrenpreis had performed repeated contrast enemas in children with HSCR and concluded that the pathology was not located to the dilated part of the colon but to the narrow distal part.…”

A significant cause of constipation and growth retardation: hirschsprung’s disease

“…These patients are prone to urinary tract infection because of the mass effect of fecaloma accumulated in the dilated bowel segment on the bladder. In this patients recurrent urinary tract infections, dilated bladder or even hydronephrosis may occur, due to urinary retention secondary to urinary system compression [2,11]. The most common complaints in patients are delayed meconium passage, abdominal distension, feeding intolerance and bile vomiting [4].…”

“…Anamnesis and physical examination are the most important steps in the evaluation of the patient presenting with constipation [11,19]. It should first be decided whether the disease is organic or functional [2,4,19]. Weight loss, growth retardation, bloody stool, constipation from early infant period; fever, accompanied by vomiting and other system findings should thought to have organic causes.…”

“…Hirschsprung's Disease (HD) was first described by the Indian surgeon Shushruta Samheta in the 17th century. In 1887, Harald Hirshsprung, a pediatrician from Copenhagen, described the disease in two patients and the disease was named after his own name [1][2][3]. HD is a motility disorder characterized by the absence of peristaltic activity in the segment of the affected intestine as a result of congenital and complete absence of the nerve plexuses of the gastrointestinal tract (myenteric: Auerbach's and submucosal: Meisner's), it occurs from a disorder in the migration of the parasympathetic ganglion cells to distal intestine, during fetal life [4][5][6][7].…”

История Изучения Сахарного Диабета В Зеркале Нумизматики

“…Історія ендокринології /History of Endocrinology/ тик та її здатність притягувати мурах[15]. У ІІ столітті давньогрецький лікар часів ранньої Римської імперії, представник школи пневматиків Аретей (~80-135) (рис.…”