Knowledge of object manipulation and object function: dissociations in apraxic and nonapraxic subjects

Buxbaum, Laurel J.; Saffran, Eleanor M.

doi:10.1016/s0093-934x(02)00014-7

Cited by 304 publications

(247 citation statements)

References 49 publications

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“…These two facts suggest that even in the final stages of her illness VZ might still rely on some knowledge of actions, perhaps supported by the activation of the affordance representation of objects. This interpretation is consistent with Buxbaum and Saffran (2002), who emphasize the role of "motor" knowledge (i.e., affordance) during the processing of objects. In this view, functional attributes are considered an indirect product of action0motor processing (see also Warrington & McCarthy, 1987;Tyler & Moss, 1998).…”

Section: Discussionsupporting

confidence: 90%

“…Knowledge of nonliving things seems to be partially sustained by functional information, and partially, but for a much longer time, by some kind of action or motor knowledge. In fact, functional and motor knowledge might be intertwined in the representations of nonliving things (Buxbaum & Saffran, 2002), which could be an interesting aspect to disentangle in future studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Progressive knowledge loss: A longitudinal case study

Mondini

Borgo

Cotticelli

et al. 2006

J Int Neuropsychol Soc

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The evolution of the progressive loss of semantic knowledge of a patient, VZ, with lesions mainly affecting the infero-medial temporal lobes, was followed for two years. At the beginning of the study VZ's performance was mainly characterized by a category-specific deficit for living things and a modality-specific deficit for perceptual attribute knowledge. As time went on, VZ's disorder affected all categories by changing the relationship between category and attribute knowledge. Data show that dissociations may change in the course of progressive cognitive breakdown, depending on both degeneration stage and task demands. VZ's performance is discussed in the light of the most influential theoretical accounts. Methodological suggestions regarding longitudinal studies of degenerative patients are also put forward. (JINS, 2006, 12, 275-284.)

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Progressive knowledge loss: A longitudinal case study

Mondini

Borgo

Cotticelli

et al. 2006

J Int Neuropsychol Soc

View full text Add to dashboard Cite

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“…Behavioral studies of apraxia patients with left parietal or caudal middle frontal lobe lesions identify deficits in the retrieval and execution of actions based on verbal commands [Haaland et al, 2000;Heilman et al, 1982] imitation [Goldenberg et al, 1996] or object centered action goals [Buxbaum and Saffran, 2002]. It remains challenging to determine if the deficit in these cases is secondary to semantic access to a particular action, the organization of an action plan or the actual execution of a motor act.…”

Section: Introductionmentioning

confidence: 99%

Repetition suppression for performed hand gestures revealed by fMRI

Hamilton

Grafton

2008

Human Brain Mapping

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Abstract:The functional components of the human motor system that are used to retrieve and execute simple intransitive hand gestures were identified with a repetition suppression (RS) paradigm. Participants performed movements with the right hand to text instructions in a rapid event related design with a pseudo-random stimulus order. Brain areas associated with action retrieval were identified by comparing trials where an action was repeated to trials that involved a new action. Performance of a novel action, collapsed across individual actions, resulted in significantly greater activity in a left hemisphere predominant fronto-parietal circuit involving inferior frontal gyrus and inferior parietal cortex (supramarginal gyrus). This is consistent with previous action retrieval tasks using go, no-go paradigms and lesion studies of patients with apraxia that emphasize a role of these areas in action organization. In addition, RS effects were present in left primary sensorimotor cortex. These effects cannot be ascribed to kinematic differences, simple action related activity or differences of cognitive set. Significant RS effects for action retrieval could be identified with as little as 5 min of fMRI data and underscores the potential of using RS to characterize representational structure within the motor system. Hum Brain Mapp 00:000-000, 2009. V V C 2008 Wiley-Liss, Inc.

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“…a computer keyboard and piano), but appropriately match items with a similar function (e.g. a lighter and a matchstick both make a flame) (Buxbaum & Saffran, 2002;Myung et al, 2010;Lee, Mirman, & Buxbaum, 2014). Notably, an eye-tracking task found that apraxic patients took longer to fixate on manipulation-related stimuli compared to non-apraxics, indicating that processing of manipulation features of object-use is maintained but less accessible (Myung et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between apraxia and left IPL damage implies that apraxic symptoms may reflect a disruption to the ventro-dorsal stream resulting in impaired access to internal motor representations necessary for accurate perception of object-use manipulation (Haaland, Harrington, & Knight, 2000;Buxbaum & Saffran, 2002;Randerath, Li, Goldenberg, & Hermsdörfer, 2009;Buxbaum & Kalénine, 2010). Akin to the dissociations found in neuroimaging data, apraxic patients make errors matching objects manipulated similarly (e.g.…”

Section: Introductionmentioning

confidence: 99%

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

et al. 2016

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This study evaluated whether apraxia can be understood as due to impaired motor representations or motor imagery necessary for appropriate object-use, imitation, and pantomime. The causal role of the left inferior parietal lobe (IPL), which is heavily implicated in apraxia, is also evaluated. These processes are appraised in light of the proposed ventro-dorsal sub-stream of the classic two visual pathway model, where perceptual information from the ventral stream and the dorsal action stream are integrated and essential for object manipulation. Using a task assessing object-use perception, stroke patients with apraxia demonstrated a selective deficit during perceptual decisions reliant on the integration of visible and known object properties to select the appropriate grasp for object-use. This deficit increased with apraxia severity. A dissociation was evident in these patients showing intact non-motoric perceptual decisions regarding the functional semantic relationship between two objects in the absence of the actor (e.g. how a hammer hits a nail). Converging evidence was found using a modified version of the same task in a neuromodulation study that directly targeted the left IPL in healthy participants using transcranial direct current stimulation (tDCS). Application of inhibitory stimulation over the left IPL reduced performance during perceptual decisions regarding object manipulation whilst performance was unaffected during functional semantic decisions. Excitatory stimulation of the left IPL did not affect performance in either task. Combined, these results suggest that the left inferior parietal lobe is critical for motor imagery, and that apraxia may be caused by an inability to use internal motor representations of object manipulation. These results are discussed in terms of motoric and non-motoric perceptual processes and the proposal of an additional ventro-dorsal sub-stream within the dorsal and ventral visual pathways model

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Knowledge of object manipulation and object function: dissociations in apraxic and nonapraxic subjects

Cited by 304 publications

References 49 publications

Progressive knowledge loss: A longitudinal case study

Progressive knowledge loss: A longitudinal case study

Repetition suppression for performed hand gestures revealed by fMRI

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

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