One of the most important problems of modern medicine, which, in particular, precludes the effective implementation of new diagnostic methods such as population screening, is the steady increase of volumes of important medical data, as well as insufficient attention to the analysis of the dynamics of the patients’ condition. These problems can be solved by the information support of medical specialist in the process of research and in the formation of recommendations for further management of patients. In the study, we examined the possible ways of solving these problems through the development of software tools for creation of knowledge bases of recommendations for monitoring and treatment of various diseases, as well as intelligent decision support by the example of cancer. The results of tests of these solutions allow speaking about their effectiveness and applicability in clinical practice.