Kochleaimplantation bei Kindern im 1. Lebensjahr

Lesinski‐Schiedat, Anke; Illg, Angelika; Warnecke, Athanasia; Heermann, R.; Bertram, Bernd; Lenarz, T

doi:10.1007/s00106-005-1260-z

Cited by 22 publications

(19 citation statements)

References 27 publications

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“…Holman et al [2013] found over 60% of correct scores of their youngest implanted children at the 12-month follow-up. Similarly, Lesinski-Schiedat et al [2005] found over 70% correct answers at several subsets of the MAIS scores on their youngest group of implanted patients (<12 months) at the 1-year follow-up. In both studies, at 21 months of age [Holman et al, 2013] and 24 months of follow-up [Lesinski-Schiedat et al, 2005], scores of both age groups varied between 80 and 100% correct scores, without differences with respect to age at CI being identified between groups.…”

Section: Speech Production Outcomesmentioning

confidence: 99%

“…The best available evidence is based on independent subjective outcome measures and indicates that implantation before the age of 2 is beneficial when considering speech perception (on combined PB-K and CNC but not on GASP scores) [Leigh et al, 2013;Dunn et al, 2014;Lesinski-Schiedat et al, 2005]. Implantation before 12 months resulted in better speech production (DEAP and IT-MAIS) [Ching et al, 2013;Leigh et al, 2013], auditory performance (CAP-II score) [Colletti et al, 2012] and two out of the five receptive language scores (combined PLS-4 and OWLS and PPVT scores) [Colletti et al, 2012;Leigh et al, 2013;Holman et al, 2013].…”

Section: Discussionmentioning

confidence: 99%

“…Uziel et al [2007] showed higher speech perception scores compared to the modeled values at 60 months of Dunn et al [2014]: 55% at 7 years of age (<2 years) and 48% at 8 years of age (2-4 years). Both studies testing children on GASP scores [Zwolan et al, 2004;Lesinski-Schiedat et al, 2005] found older implanted children (implanted above 12 and 36 months, respectively) to perform better at the 12-month follow-up. However, after 24 months of follow-up, the youngest implanted children (<12 months [Le sinski-Schiedat et al, 2005] and between 1 and 3 years [Zwolan et al, 2004]) outperformed the older implanted children (nonsignificant) in both studies (table 2).…”

Section: Speech Perception Outcomesmentioning

confidence: 99%

“…Studies compared similar age groups, but 1 study [Holman et al, 2013] combined IT-MAIS with LittlEARS questionnaire scores, whereas only MAIS scores were applied in the study of Lesinski-Schiedat et al [2005]. Holman et al [2013] found over 60% of correct scores of their youngest implanted children at the 12-month follow-up.…”

Section: Speech Production Outcomesmentioning

confidence: 99%

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A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation

et al. 2016

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Objective: This review aimed to evaluate the additional benefit of pediatric cochlear implantation before 12 months of age considering improved speech and language development and auditory performance. Materials and Methods: We conducted a search in PubMed, EMBASE and CINAHL databases and included studies comparing groups with different ages at implantation and assessing speech perception and speech production, receptive language and/or auditory performance. We included studies with a high directness of evidence (DoE). Results: We retrieved 3,360 articles. Ten studies with a high DoE were included. Four articles with medium DoE were discussed in addition. Six studies compared infants implanted before 12 months with children implanted between 12 and 24 months. Follow-up ranged from 6 months to 9 years. Cochlear implantation before the age of 2 years is beneficial according to one speech perception score (phonetically balanced kindergarten combined with consonant-nucleus-consonant) but not on Glendonald auditory screening procedure scores. Implantation before 12 months resulted in better speech production (diagnostic evaluation of articulation and phonology and infant-toddler meaningful auditory integration scale), auditory performance (Categories of Auditory Performance-II score) and receptive language scores (2 out of 5; Preschool Language Scale combined with oral and written language skills and Peabody Picture Vocabulary Test). Conclusions: The current best evidence lacks level 1 evidence studies and consists mainly of cohort studies with a moderate to high risk of bias. Included studies showed consistent evidence that cochlear implantation should be performed early in life, but evidence is inconsistent on all speech and language outcome measures regarding the additional benefit of implantation before the age of 12 months. Long-term follow-up studies are necessary to provide insight on additional benefits of early pediatric cochlear implantation.

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Section: Speech Production Outcomesmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Speech Perception Outcomesmentioning

confidence: 99%

Section: Speech Production Outcomesmentioning

confidence: 99%

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A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation

et al. 2016

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“…Umso wichtiger ist es daher, das geschä-digte Ohr z. B. durch Hörhilfen zu verbessern [1,2,13]. In jüngster Zeit wird ein neuer Ansatz erforscht: das Ersetzten geschädigter oder abgestorbener Haarzellen durch Stammzellen.…”

Section: Stammzelltransplantation In Die Kochlea Originalienunclassified

Neurogene Stammzelltransplantation in die Kochlea

Nagy

Fuchs

Monge

et al. 2007

HNO

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In den letzten Jahren hat die Forschung an und mit Stammzellen großes Interesse auf sich gezogen, da diese Zellen das Potenzial haben, defekte oder abgestorbene Zellen im Organismus zu ersetzen. Je nach Typ und Umgebung, in die sie eingebracht werden, können sich Stammzellen in ganz unterschiedliche Zelltypen entwickeln.Interessant ist insbesondere die Anwendung von Stammzellen im Innenohr [5,17,21]. Die Haarzellen stellen die empfindlichsten Elemente im Innenohr dar, und ihre Schädigung bzw. ihr Tod ist der häufigste Grund für eine Schallempfindungsschwerhörigkeit. Da Haarzellen bei Säugetieren, anders als bei manchen Vö-geln und Amphibien, nicht regenerieren, führt ihr Tod zu einem irreversiblen Gehörsverlust. Patienten mit einem Hörver-lust aufgrund unterschiedlichster Ursachen [11] verlieren an Lebensqualität [12]. Umso wichtiger ist es daher, das geschä-digte Ohr z. B. durch Hörhilfen zu verbessern [1,2,13] Infektion der Vorläuferzellen mit einem GFP-exprimierenden AdenovirusDie Vorläuferzellen wurden mit einem Adenovirus infiziert, der GFP exprimiert (500 Viruspartikel pro Zelle); 16 Stunden nach Infektion wurden die Zellen gewaschen, in PBS Lösung aufgenommen und transplantiert. Charakterisierung der neurogenen VorläuferzellenDie GFP + -neuralen Vorläuferzellen wurden mit 4% Paraformaldehyd in PBS fixiert und mit 5% Triton X-100 in PBS zusammen mit 10% FBS permeabilisiert. Folgende Antikörper wurden verwendet, um die Vorläuferzellen zu charakterisieren: Nestin (Maus, monoklonal, #556309, BD Biosciences, Schweiz) 1:200 2 h bei Raumtemperatur, Sox-2 (Kaninchen, monoklonal, S7693, Sigma Aldrich Chemie, Schweiz) 1:200 2 h bei Raumtemperatur, Myosin VIIa (Ziege, polyklonal, A-16, Santa Cruz Biotechnology, Santa Cruz, USA) 1:100 2 h bei Raumtemperatur, Tuj1 (Maus, monoklonal, C4585, Sigma-Aldrich Chemie, Schweiz) 1:100 2 h bei Raumtemperatur, Math1 (Kaninchen, polyclonal, Abcam, Cambridge, England) 1:100 2 h bei Raumtemperatur, Texas Red X-phalloidin (Molecular Probes, Eugene, USA) 1:300 für 1 h bei Raumtemperatur. Die entsprechenden sekundären fluoreszierenden Antikörper wurden für 1 h bei Raumtemperatur inkubiert (Santa Cruz Biotechnology, Santa Cruz, USA; 1:300). Die Zellkerne wurden mit DAPI gefärbt (1 min). Die Zellen wurden mit einem Fluoreszenzmikroskop (Olympus, Schweiz) visualisiert und photographiert (AxioCam Carl Zeiss, Schweiz; . Abb. 2). Transplantation von Vorläuferzellen auf Innenorexplantate in vitroIn Zellkulturplatten, die jeweils 3 CortiOrgane enthielten, wurden 2×104 GFP + -neurogene Vorläuferzellen transferiert. Die infizierten Explantate wurde daraufhin in serumfreiem Medium mit N2 Supplement, 20 ng/ml EGF, 10 ng/ml bFGF und 50 ng/ml IGF-1 für 7 Tage kultiviert. ImmunhistochemieNach der Kultivierung wurden die Innenohrexplantate zusammen mit den adhärenten GFP + -Vorläuferzellen in 4% Paraformaldehyd fixiert und mittels 5% Triton X-100 in PBS zusammen mit 10% FBS permeabilisiert. Anschließend erfolgte die Inkubation der Corti-Explantate mit Texas Red X-phalloidin (1:300; Molecular Probes,...

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Diagnostik und Therapie der auditorischen Synaptopathie/Neuropathie

Moser

Strenzke

Meyer

et al. 2006

HNO

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Pathological auditory brainstem responses (lack of responses, elevated thresholds and perturbed waveforms) in combination with present otoacoustic emissions are typical audiometric findings in patients with a hearing impairment that particularly affects speech comprehension or complete deafness. This heterogenous group of disorders first described as "auditory neuropathy" includes dysfunction of peripheral synaptic coding of sound by inner hair cells (synaptopathy) and/or of the generation and propagation of action potentials in the auditory nerve (neuropathy). This joint statement provides prevailing background information as well as recommendations on diagnosis and treatment. The statement focuses on the handling in the german language area but also refers to current international statements.

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Kochleaimplantation bei Kindern im 1. Lebensjahr

Cited by 22 publications

References 27 publications

A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation

A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation

Neurogene Stammzelltransplantation in die Kochlea

Diagnostik und Therapie der auditorischen Synaptopathie/Neuropathie

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