Koebner Phenomenon in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)

Tourte, M.; Lheure, C.; Gras, Julien; Battistella, Maxime; Simon, Isabelle; Hussenet, C.; Bagot, M.; Tazi, A; Bergeron, Anne; Bouaziz, Jean‐David

doi:10.2340/00015555-2683

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…To date, only two cases of the Koebner phenomenon have been reported in patients with ANCA-associated vasculitis; in one, a patient with recurring leg ulcers was found to have a high level of perinuclear ANCAs. 10,11 MANAGEMENT Our patient received induction therapy with oral corticosteroids, 0.7 mg/kg/day, and rituximab, 375 mg/m 2 , once weekly for 4 weeks, according to recommendations from the European Vasculitis Society. 12 Rituximab is thought to deplete the population of B cells with a CD20 marker; B cells responsible for the manufacture of ANCAs.…”

mentioning

confidence: 99%

Bilateral Breast Ulcers: Granulomatosis with Polyangiitis

Jarrot

Pelletier²,

Brun

et al. 2019

The American Journal of Medicine

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mentioning

confidence: 99%

Bilateral Breast Ulcers: Granulomatosis with Polyangiitis

Jarrot

Pelletier²,

Brun

et al. 2019

The American Journal of Medicine

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“…Inflammatory dermatosis [154] Coffin-Siris syndrome [155] Churg-Strauss syndrome [156] Cryoglobulinemia [157] Leukocytoclastic vasculitis [158] Drug reaction (Labetalol, Clindamycin, Sorafenib) [159][160][161][162] Virus infection (Hand-foot-andmouth disease, Virus varicella zoster) [163,164] one case study reported that a patient with psoriasis vulgaris developed a new psoriatic lesion following tissue dilator insertion after total mastectomy for right breast cancer. These findings indicate that mechanical stretch-induced lesions as a consequence of KP.…”

Section: Vaccination [129]mentioning

confidence: 99%

Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

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The Koebner phenomenon, also known as isomorphic reaction, refers to the development of secondary lesions with the same clinical manifestations and histopathological characteristics as the primary lesions in normal skin after trauma or other stimuli. The triggering factors of Koebner phenomenon include physical trauma, chemical stimulation, mechanical stress, iatrogenic stimulation and pathogenic infection. Vitiligo, psoriasis and lichen planus are considered true Koebner phenomenon. Recent studies have shown that immunological disorders, oxidative stress, defective melanocyte adhesion and growth factor deficiency are the main pathological mechanisms of vitiligo Koebner phenomenon. In psoriasis, triggers may drive skin inflammation to induce a psoriatic phenotype through multiple signalling pathways and thereby cause Koebner phenomenon in susceptible individuals. Significantly, keratinocytes mediate the occurrence of Koebner phenomenon in psoriasis through mechano‐induced signalling pathways after sensing mechanical signals and explains the high frequency of psoriasis lesions on the extensor side of the elbow and knee joints. On the contrary, TRPA1‐driven mechano‐transduction, autoimmunity and actinic damage are the underlying mechanisms of Koebner phenomenon in lichen planus. In this review, we have summarized the current understanding of the characteristics and pathogenesis of Koebner phenomenon.

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Koebner Phenomenon in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)

Cited by 2 publications

References 2 publications

Bilateral Breast Ulcers: Granulomatosis with Polyangiitis

Bilateral Breast Ulcers: Granulomatosis with Polyangiitis

Characteristics and pathogenesis of Koebner phenomenon

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