Kognitive Störungen: Koma, Delir, Demenz

Förstl, Hans

doi:10.1007/3-540-30887-3_5

Cited by 10 publications

(6 citation statements)

References 396 publications

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“…Furthermore, the apolipoprotein E (apoE) genotype was determined using the LightCycler technology (Aslanidis & Schmitz, 1999). In the overall sample of n = 288 participants, for whom apoE was available at T3, allelic frequency (apoE ε2: 10.2%, apoE ε3: 72,6%, apoE ε4: 17.2%) was comparable to findings in a representative study in Germany (Förstl, 2006). For the n = 205 included in this study, allelic frequency of participants with at least one apoE ε4 was slightly higher (25% vs. 15% reported by Förstl, 2006).…”

Section: Methodssupporting

confidence: 69%

Attitude toward own aging as a risk factor for cognitive disorder in old age: 12-year evidence from the ILSE study.

Siebert

Wahl

Degen

et al. 2018

Psychology and Aging

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Previous research has demonstrated the harmful impact of subjective aging processes (e.g., negative age self-stereotyping) on normal cognitive aging in different domains of cognitive functioning, such as memory, executive function, and fluid abilities. Recently, subjective aging has also been linked to important biomarkers of Alzheimer's disease (AD) and dementia-related outcomes, indicating associations with pathological cognitive aging. With data from the Interdisciplinary Longitudinal Study of Adult Development and Aging (ILSE), the present study extends this research by examining the long-term effect of attitude toward own aging (ATOA) on expert-based clinical diagnosis of mild cognitive impairment (MCI) and AD in old age. In the study, 260 initially cognitively healthy participants with a mean age of 62.5 years were followed for 12 years. In the course of the study, 103 participants developed MCI and 14 received diagnosis of AD. Logistic regression models showed that baseline ATOA predicted future clinical diagnoses of MCI and AD 12 years later, while controlling for sociodemographic, genetic, and health variables. Although theoretically suggested, evidence for a mediating role of leisure-activity level and control beliefs was scarce. Our findings add to the emerging literature supporting negative views of aging as a risk factor for cognitive disorder in old age. (PsycINFO Database Record

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Section: Methodssupporting

confidence: 69%

Attitude toward own aging as a risk factor for cognitive disorder in old age: 12-year evidence from the ILSE study.

Siebert

Wahl

Degen

et al. 2018

Psychology and Aging

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“…S18). Lewy himself noted the conundrum of distinguishing between the two 26 , and it has remained a challenge throughout the past century. It cannot be excluded that some of the structures previously analyzed by EM and published as a characterization of Lewy structures were in fact CA 19 .…”

Section: Discussionmentioning

confidence: 99%

Lewy pathology in Parkinson’s disease consists of a crowded organellar, membranous medley

Sharamoradian¹,

Britschgi

Stahlberg³

et al. 2017

Preprint

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SummaryParkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites, which are neuronal inclusions that are immunopositive for the protein α-synuclein. In-depth ultrastructural analysis of this Lewy pathology is crucial to understanding pathogenesis and progression of the disease. Using correlative light and electron microscopy/tomography on brain tissue from five Parkinson’s disease brain donors, we identified α-synuclein immunopositive Lewy pathology and could show that the majority of these features including Lewy bodies and Lewy neurites primarily consists of a crowded membranous medley of vesicular structures and dysmorphic organelles. Only a small fraction of observed Lewy bodies contained predominant proteinaceous filaments, as previously described. The crowding of organellar components was confirmed by STED- based super-resolution microscopy, and high lipid content within the α-synuclein immunopositive inclusions was corroborated by confocal imaging, CARS/FTIR imaging and lipidomics. Applying this correlative high-resolution imaging and biophysical approach, we discovered in the postmortem brain of Parkinson’s patients a subcellular protein-lipid compartmentalization not previously described in Lewy pathology.

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“…Yet age of onset of symptoms – not general age – is generally seen as the crucial marker predicting the course of dementia. General age is far less important because the pathology of dementia affecting cognition, psychopathology, and behavior is fundamentally different from the decline found in normal aging (Förstl, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Medications like acetylcholinesterase inhibitors and the NMDA-antagonist memantine can slow down the progression and temporarily delay cognitive decline (Förstl, 2006). In dementia, especially neuropsychiatric symptoms like depression, psychotic symptoms, anxiety, agitation, or depression frequently cause considerable suffering in patients and caregivers.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a TEACCH- and Music Therapy-Based Psychological Intervention in Mild to Moderate Dementia

Fischer-Terworth

Probst

2011

GeroPsych

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Background: A multicomponent psychological intervention designed to alleviate neuropsychiatric symptoms and to improve communication in mild to moderate dementia was evaluated in a controlled trial. Components were (1) TEACCH (Treatment and Education of Autistic and related Communication handicapped Children)-based cognitive-behavioral and environmental interventions adapted for dementia and (2) music therapy. Methods: In a Pre-post design, the treatment group (n = 26) received the program for 6 months, whereas controls (n = 23) participated in nonspecific occupational therapy. Statistical analyses included t-tests, effect sizes, and two-way ANOVAs. Results: Relative to controls, the treatment group showed partly significant reductions of agitation, aggression, apathy, and anxiety, and improvement of communication, emotional expression, and activity. Conclusion: The intervention can help to increase psychological well-being in patients with dementia.

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Kognitive Störungen: Koma, Delir, Demenz

Cited by 10 publications

References 396 publications

Attitude toward own aging as a risk factor for cognitive disorder in old age: 12-year evidence from the ILSE study.

Attitude toward own aging as a risk factor for cognitive disorder in old age: 12-year evidence from the ILSE study.

Lewy pathology in Parkinson’s disease consists of a crowded organellar, membranous medley

Evaluation of a TEACCH- and Music Therapy-Based Psychological Intervention in Mild to Moderate Dementia

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