Kognitive Störungen und Schlafstörungen bei Long-COVID

Schilling, Cláudia; Meyer‐Lindenberg, Andreas; Schweiger, Janina I.

doi:10.1007/s00115-022-01297-z

Cited by 15 publications

(14 citation statements)

References 80 publications

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“…Another interpretation may involve the role of sleep loss as a driver of cellular stress and the consequent neuronal damage 54 in the cognitive and neuropsychiatric manifestations of long COVID. 55…”

Section: Discussionmentioning

confidence: 99%

Poor sleep quality, insomnia, and short sleep duration before infection predict long-term symptoms after COVID-19

Salfi

Amicucci

Corigliano

et al. 2023

Preprint

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Study objectives: Millions of COVID-19 survivors experience a wide range of long-term symptoms after acute infection, giving rise to serious public health concerns. To date, few risk factors for post-COVID-19 conditions have been determined. This study evaluated the role of pre-infection sleep quality/duration and insomnia severity in the incidence of long-term symptoms after COVID-19. Methods: This prospective study involved two assessments (April 2020 and 2022). At baseline, sleep quality/duration and insomnia symptoms in participants without current/prior SARS-CoV-2 infection were measured using the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI). At follow-up, we evaluated the presence of twenty-one symptoms (psychiatric, neurological, cognitive, bodily, and respiratory) one month (n=713, infection in April 2020-February 2022) and three months after COVID-19 (n=333, infection in April 2020-December 2021). Zero-inflated negative binomial models were used to estimate the effect of previous sleep on the number of long-term symptoms. Binomial logistic regressions were performed to evaluate the association between sleep outcomes and the incidence of each post-COVID-19 symptom. Results: Analyses highlighted a significant effect of pre-infection sleep on the number of symptoms one/three months after COVID-19. Previous higher PSQI and ISI scores, and shorter sleep duration significantly increased the risk of almost every long-term symptom at one/three months from COVID-19. Conclusion: This study suggested a prospective dose-dependent association between pre-infection sleep quality/quantity and insomnia severity with the manifestation of post-COVID-19 symptoms. Promoting sleep health may represent an effective preventive approach to mitigate the COVID-19 sequelae, with substantial public health and societal implications.

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Section: Discussionmentioning

confidence: 99%

Poor sleep quality, insomnia, and short sleep duration before infection predict long-term symptoms after COVID-19

Salfi

Amicucci

Corigliano

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, sleep disturbance in long COVID overlaps with, and is difficult of differentiate from, fatigue and cognitive dysfunctions. This highlights the importance of a differentiated assessment of sleep disturbances vs. fatigue with the aim of guiding treatment [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sleep disorders can induce mild inflammation, causing blood–brain barrier dysfunctions and allowing antigens and inflammatory mediators passage into the CNS. In this respect, pre-existing sleep disturbances in the context of long COVID could adversely influence the long-term course of COVID-19 disease [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

et al. 2022

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Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms, generally referred to as long COVID. Sleep disorders are one of the most frequent complaints in long COVID although precise data are missing. We assessed the sleep behavior of children and adolescents who presented at our outpatient clinic between January 2021 and May 2022 with the Children’s Sleep Habits Questionnaire (CSHQ-DE). We compared the sleep behavior at three different time points: pre-COVID-19; post-COVID-19 at the initial presentation; and post-COVID-19 at re-presentation. Data from 45 patients were analyzed. Of those, 64% were female and the median age was 10 years (range: 0–18 years). Asymptomatic or mild COVID-19 disease was experienced in 89% of patients; 11% experienced moderate disease. The initial presentation occurred at a median of 20.4 weeks (6 weeks–14 months) after the infection. The CSHQ-DE score increased significantly from pre-COVID-19 (45.82 ± 8.7 points) to post-COVID-19 (49.40 ± 8.3 points; p ≤ 0.01). The score then normalized at re-presentation (46.98 ± 7.8; p = 0.1). The greatest changes were seen in the CSHQ-DE subscale score “daytime sleepiness”. Our data showed that children and adolescents with long COVID often suffer from sleep disturbances. For most children and adolescents, these sleep disorders decreased over time without any further medical intervention aside from a basic sleep consultation.

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“…Therefore, sleep disturbance in long COVID overlaps with, and is difficult of differentiate from, fatigue and cognitive dysfunction. This highlights the importance of a differentiated assessment of sleep disturbances versus fatigue, with the aim to guide treatment [33].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sleep disorders can induce mild inflammation causing bloodbrain barrier dysfunction, allowing antigens and inflammatory mediators passage into the CNS. In this respect, preexisting sleep disturbances in the context of long COVID could adversely influence the long-term course of COVID-19 disease [33].…”

Section: Discussionmentioning

confidence: 99%

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Werner¹,

Doerfel²,

Biedermann³

et al. 2022

Preprint

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Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms generally referred as long COVID. Sleep disorders are one of the most frequent complaints in long COVID although precise data are missing. We assessed the sleep behavior of children and adolescents who presented at our outpatient clinic between January 2021 and May 2022 with the Children's Sleep Habits Questionnaire (CSHQ-DE). We compared sleep behavior at three different time points: pre-COVID-19, post-COVID-19 at initial presentation and post-COVID-19 at re-presentation. Data from 45 patients were analyzed. Of those, 64% were female and the median age was 10 years (range 0-18 years). Asymptomatic or mild COVID-19 disease was experienced in 89% of patients, whilst 11% experienced moderate disease. Initial presentation occurred at a median of 20.4 weeks (6 weeks - 14 months) after infection. The CSHQ-DE score increased significantly from pre-COVID-19 (45.82+8.7 points) to post-COVID-19 (49.40+8.3 points; p=&lt;0.01). The score then normalized at re-presentation (46.98+7.8; p=0.1). The greatest changes were seen in the CSHQ-DE subscale score "daytime sleepiness". Our data show that children and adolescents with long COVID often suffer from sleep disturbance. For most children and adolescents these sleep disorders decreased over time without further medical intervention, aside from a basic sleep consultation.

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Kognitive Störungen und Schlafstörungen bei Long-COVID

Cited by 15 publications

References 80 publications

Poor sleep quality, insomnia, and short sleep duration before infection predict long-term symptoms after COVID-19

Poor sleep quality, insomnia, and short sleep duration before infection predict long-term symptoms after COVID-19

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

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