Kolanone, a Novel Polyisoprenylated Benzophenone with Antimicrobial Properties from the Fruit ofGarcinia kola

Abstract

Kolanone, a novel polyisoprenyl benzophenone, has been isolated from the fruit pulp of Garcinia kola HEK-KEL. A tentative structure for kolanone has been proposed based on a comparison of its spectral data with that published for other compounds of this class. Kolanone has been shown to exhibit significant antimicrobial activity against a range of organisms.

Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts

“…Nervous alertness and induction of insomnia, purgative, wound healing (Uko et al, 2001) Roots, seeds, latex Seeds (22.19) Antimicrobial; kolanone kolaflavanone and garciniaflavanone (Iwu, 1993;Hussain et al, 1982) Psorospermum adamauense (9826/SRFCam) Febrifugal, anti-poison, purgative, leprosy, skin diseases such as dermatitis, scabies and eczemas, subcutaneous wounds (Irvine, 1961;Watt and Brayer-Brandwijk, 1962;Uphof, 1968) Bark, leaves, roots…”

Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN

“…These classes of natural products include numerous bioactive compounds. A series of polyprenylated benzophenones, the guttiferones, exhibit pronounced anti-microbial and anti-HIV activities (Hussain et al 1982;Fuller et al 1999). Some prenylated xanthones possess strong anti-bacterial activity against methicillin-resistant Staphylococcus aureus, and they inhibit eciently the DNA topoisomerases I and II (Iinuma et al 1996;Tosa et al 1997).…”

Glycolysis Inhibitor Screening Identifies the Bis-geranylacylphloroglucinol Protonophore Moronone from Moronobea coccinea

“…The UV spectrum showed absorptions at 237, 281, and 351 nm indicating the presence of a α,β-conjugated benzophenone chromophore (1,3-diketone system). 23 The IR spectrum supported the presence of an α,β-conjugated carbonyl group (1642 cm −1 ) and OH groups (3510 cm −1 ) in 1 . The NMR spectra of 1 contained resonances for a benzophenone group [δ H 7.84 (2H, d, J = 7.2 Hz, H-9, 13), 7.46 (3H, overlapped, H-10, 11, 12); δ C 198.0 (C-7), 142.0 (C-8), 132.1 (C-11), 130.0 (C-9, 13), 129.1 (C-10, 12)] and two geranyl moieties [δ H 5.51 (2H, t, J = 7.2 Hz, H-2′, 2″), 5.17 (2H, t, J = 6.4 Hz, H-6′, 6″), 3.02 (4H, overlapped, H 2 -1′, 1″), 2.15 (4H, overlapped, H 2 -5′, 5″), 2.07 (4H, overlapped, H 2 -4′, 4″), 1.79 (6H, s, H 3 -10′, 10″), 1.66 (6H, s, H 3 -8′, 8″), 1.56 (6H, s, H 3 -9′, 9″); δ C 139.5 (C-3′, 3″), 132.6 (C-7′, 7″), 125.9 (C-6′, 6″), 120.8 (C-2′, 2″), 41.4 (C-4′, 4″), 39.3 (1′, 1″), 28.2 (C-5′, 5″), 27.0 (C-8′, 8″), 19.0 (C-9′, 9″), 17.9 (C-10′, 10″], that were assigned based on the interpretation of HSQC and HMBC data.…”