Kolaviron attenuates cardiovascular injury in fructose-streptozotocin induced type-2 diabetic male rats by reducing oxidative stress, inflammation, and improving cardiovascular risk markers

Adoga, Jeffrey O.; Channa, Mahendra L.; Nadar, Anand

doi:10.1016/j.biopha.2021.112323

Cited by 13 publications

(12 citation statements)

References 95 publications

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“…caspase reduction/cleavage), and reperfusion injury signaling kinase (RISK) (Oyagbemi et al 2017 , 2018a ). In a more recent study, KV also reduced cardiovascular injury in fructose-streptozotocin induced diabetic rats (Adoga et al 2021 ). Furthermore, KV showed cardioprotective effect in animal models against various cardiotoxic agents, including antitumour drugs, and antimalarial agents (e.g.…”

Section: Resultsmentioning

confidence: 87%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from G. kola, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of G. kola. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in G. kola may be used as a lead in the drug development.

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Section: Resultsmentioning

confidence: 87%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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“…Kolaflavanone, Kolafavone, and Garcinia bioflavonoids I & II are flavonoids present in Kolaviron which is an extract of Garcinia kola [11][12][13] Kolaviron (KV) is the defatted ethanol extract of Garcinia kola seeds which is widely available in the Southern part of Nigeria. 14 Proven pharmacological effects of KV include its antiinflammatory and hepatoprotective, [15][16][17] analgesic, 17 antioxidant, [18][19][20][21] hypoglycaemic, 22,23 anti-ulcer, 24 anti-malarial, 25 antiviral, 12 cholesterol lowering, [26][27][28] alpha-glucosidase inhibitory, 29 aromatase inhibitory, 29 antiplasmodial, 29 and antihypertensive 26,27 effects. KV has also been proven to be safe.…”

Section: Introductionmentioning

confidence: 75%

“…Additionally, KV has been reported to reduce the activity of the Angiotensin converting enzyme and improve the levels of endothelial NOS (eNOS). 27 eNOS is the enzyme required for the production of NO. An increase in the level of eNOS will therefore lead to an increase in the production and bioavailability of NO.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effect of Kolaviron, a Bioflavonoid From Garcinia kola, in L-NAME Induced Hypertension in Rats

Olatoye

Akindele

Balogun

et al. 2023

Natural Product Communications

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The antihypertensive effect of Kolaviron (KV) has been demonstrated in ethanol- and sucrose-model of hypertension in our previous studies. However, there remains a need to further confirm and validate this effect in other models of hypertension. This study was devised to appraise the antihypertensive action of KV in N(G)-nitro-L-arginine methyl ester (L-NAME) induced experimental format of hypertension. Thirty-six (36) male Wistar rats were divided into 6 groups of 6 animals each. Group I represents the control group while Group II animals received L-NAME 40 mg/kg only. Groups III to V animals received L-NAME 40 mg/kg and 50, 100, and 200 mg/kg KV, respectively. Group VI animals received L-NAME 40 mg/kg and 0.14 mg/kg Lisinopril (LIS). Treatment was done orally for 28 days after which blood pressure was determined via the invasive method. After this, vital organs and blood were retrieved for analysis. KV and LIS elicited significant contraction ( P < .01-.001) in blood pressure producing up to 27%, 24%, and 22% reduction in systolic blood pressure, diastolic blood pressure, and mean arterial pressure, respectively. In addition, KV elicited a notable rise ( P < .05-.001) in catalase, reduced glutathione, and superoxide dismutase in the blood and vital organs. Results from this study further demonstrate and confirm that KV possesses notable blood pressure-lowering effect possibly through its well-documented antioxidant effect. Additional studies are advocated to validate the results from this study and determine the precise mechanism for the antihypertensive action of KV.

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“…These activities or effects include and may not be limited to their antimalarial [ 31 ], antiplasmodial [ 32 ], antiviral [ 27 ], antifungal and bactericidal [ 33 ], anti-ulcer [ 34 ], analgesic [ 35 ], antioxidant [ [36] , [37] , [38] , [39] ], anti-inflammatory and hepatoprotective [ 35 , 40 ], hypoglycaemic [ 25 , 41 ], aromatase and alpha-glucosidase inhibitory [ 32 ] effects. Additionally, the hypolipidaemic, anti-atherogenic, lipid improvement, and cardioprotective effects of KV and GK have been documented in the literature [ [41] , [42] , [43] , [44] , [45] , [46] , [47] ]. Our previous studies reported the antihypertensive, hypolipidaemic, lipid improvement, and long-term safety of KV and GK [ 21 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

The role of Kolaviron, a bioflavonoid from Garcinia kola, in the management of cardiovascular diseases: A systematic review

Olatoye,

Akindele,

Awodele

2024

Heliyon

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Kolaviron attenuates cardiovascular injury in fructose-streptozotocin induced type-2 diabetic male rats by reducing oxidative stress, inflammation, and improving cardiovascular risk markers

Cited by 13 publications

References 95 publications

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Antihypertensive Effect of Kolaviron, a Bioflavonoid From Garcinia kola, in L-NAME Induced Hypertension in Rats

The role of Kolaviron, a bioflavonoid from Garcinia kola, in the management of cardiovascular diseases: A systematic review

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