Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Bölzner, C; Müller, Alexandra; Bräunig, E.; Hein, Gustavo Juan

doi:10.1007/s00393-003-0490-2

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…An increased crosslink excretion reflects an increased turnover and degradation of articular cartilage, as well as an increased bone resorption ( 52 , 53 ) . The correlations between the urinary crosslinks, inflammation markers and disease activity in the present study and from the previous data ( 51 , 54 55 ) substantiate an association between rheumatic inflammation processes and collagen degradation.…”

Section: Discussionsupporting

confidence: 90%

Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis

Dawczynski

Schubert

Hein

et al. 2009

BJN

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n-3 long-chain PUFA (n-3 LC-PUFA) may improve cardiovascular and inflammatory diseases. The effects of n-3 LC-PUFA-supplemented dairy products on inflammation and immunological parameters, biomarkers of oxidative stress, serum lipids, and on disease activity were determined in patients with rheumatoid arthritis (RA). Forty-five subjects (forty-three females and two males) were randomly divided into two groups in a double-blind, placebo-controlled cross-over study. Both groups received placebo or verum products consecutively for 3 months with a 2-month washout phase between the two periods. Blood samples were taken at the beginning and at the end of each period. The dairy products generally improved serum lipids by increasing HDL and lowering lipoprotein a. The n-3 LC-PUFA supplements act to lower TAG. Additionally, a decreased lipopolysaccharide-stimulated cylo-oxygenase-2 expression was found in patients who had consumed the enriched dairy products. The majority of the CD analysed were not influenced, although n-3 LC-PUFA did suppress the immune response as lymphocytes and monocytes were found to be significantly decreased. The n-3 LC-PUFA did not increase the biomarkers of oxidative stress such as 8-iso-PGF2α and 15-keto-dihydro PGF2α, and DNA damage like 7,8-dihydro-8-oxo-2′-deoxyguanosine. The long-term consumption of dairy products (2 × 12 weeks) diminished the excretion of hydroxypyridinium crosslinks, and favoured the diastolic blood pressure. The consumption of moderate doses of n-3 LC-PUFA in combination with dairy products did not improve the disease activity. However, there is evidence of cardioprotective effects. Furthermore, the long-term consumption of dairy products acts against the cartilage and bone destruction in RA.

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Section: Discussionsupporting

confidence: 90%

Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis

Dawczynski

Schubert

Hein

et al. 2009

BJN

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Prevalence and annual incidence of vertebral fractures in patients with ankylosing spondylitis

Feldtkeller¹,

et al. 2005

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Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Abstract: From our investigations, we assume that osteoporosis in AS is primarily caused by an inflammatory-mediated degradation of bone.

Cited by 2 publications

References 15 publications

Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis

Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis

Prevalence and annual incidence of vertebral fractures in patients with ankylosing spondylitis

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