Kolon- und Rektumkarzinom

Link, K. H.

doi:10.1159/000086099

Cited by 2 publications

(5 citation statements)

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“…Its management is difficult and a wide range of recurrence rates after operation for rectal cancer has been reported from 3% to 35% [20,21]. Excision of the mesorectum and neoadjuvant treatment have dramatically decreased the recurrence rates after rectal cancer surgery [5,11]. Local recurrence developed in 10 (18.2%) patients in our study with only three (10.7%) in the neoadjuvant radiochemotherapy group compared with seven (25.9%) in the adjuvant therapy group.…”

Section: Discussionmentioning

confidence: 72%

“…Many, despite their large size, are potentially curable, especially if the regional lymph nodes are free of metastasis [1,9,10]. The goals of the treatment of rectal cancer are to cure and to maintain a good quality of life, including urinary and sexual function [5,11]. It is important to recognize the nature of these tumours preoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to recognize the nature of these tumours preoperatively. Careful preoperative staging and the use of neoadjuvant treatment followed by an appropriate surgical procedure provide a favourable prognosis [1,5,12]. The beneficial effect of radiochemotherapy prior to surgery for locally advanced rectal carcinoma is well documented.…”

Section: Discussionmentioning

confidence: 99%

“…Chemoradiotherapy (CRT) with surgery for locally advanced rectum cancer provides survival benefit. Given preoperatively CRT may reduce tumour size, facilitate resection with safe distal and lateral margins and increase the possibility of using a sphincter saving procedure [5–7].…”

Section: Introductionmentioning

confidence: 99%

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Multivisceral resections for locally advanced rectal cancer

Derıcı¹,

Ünalp²,

Kamer³

et al. 2007

Colorectal Disease

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multivisceral resections for locally advanced rectal cancer

Derıcı¹,

Ünalp²,

Kamer³

et al. 2007

Colorectal Disease

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“…Its management is difficult and a wide range of recurrence rates after operation for rectal cancer has been reported from 3 to 35% [57,58]. Total mesorectal excision and neoadjuvant treatment have dramatically decreased the recurrence rates after rectal cancer surgery [59,60]. From recent Dutch data, the 5-year local recurrence rate is 11.0% after TME-based surgery alone and 4.6% when TME is performed after preoperative radiotherapy [61].…”

Section: T4 Rectalmentioning

confidence: 99%

Multivisceral Resection for T4 or Recurrent Colorectal Cancer

Larkin

O'Connell²

2012

Dig Dis

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Background: Approximately 10% of patients with colorectal cancer have locally advanced disease with peritoneal involvement (T4a) or invasion of adjacent organs (T4b) at the time of diagnosis. Of patients who undergo resection with curative intent, between 7 and 33% develop isolated locoregional recurrences. R0 surgical excision is potentially curative. Methods: We reviewed the literature relating to multivisceral resection for T4 or recurrent colorectal cancer. Results: Comprehensive staging to identify the local and systemic extent of disease is essential to determine resectability and patient suitability for a curative approach. PET scans and pelvic MRI (rectal) staging and a coordinated multispecialty input to neoadjuvant treatment, multivisceral surgical resection, reconstruction and adjuvant chemotherapy are essential. Intraoperative radiotherapy and hyperthermic intraperitoneal chemotherapy may have a role in selected patients. R0 resection can achieve 5-year local control rates for primary locally advanced and recurrent colorectal cancer of up to 89 and 38%, respectively, and overall 5-year survival up to 66 and 25%, respectively. Conclusion: An aggressive surgical strategy as part of a multimodal strategy in the treatment of locally advanced or recurrent colorectal cancer in the absence of incurable metastatic disease affords the best prospect for long-term survival in selected patients.

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Kolon- und Rektumkarzinom

Cited by 2 publications

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Multivisceral resections for locally advanced rectal cancer

Multivisceral resections for locally advanced rectal cancer

Multivisceral Resection for T4 or Recurrent Colorectal Cancer

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