Diarrhea is still a health threat because it causes illness and death, especially in toddlers. Diarrhea will increase due to consuming food contaminated with microorganisms, including through the intermediary of flies. The use of chemical pesticides can impact vector resistance, non-target insects, and health problems. The study aimed to evaluate plants effective as bioinsecticides to control house fly (Musca domestica). The study used a completely randomized design factorial. House flies from residential areas are rearing in two stages. Three types of plant leaves (Averrhoa bilimbi, Catharanthus roseus, and Annona muricata) were extracted, and their effectiveness was tested through a bioassay-test. The experiment was carried out in two replications, at various doses (25, 30, 35, 40%) and contact time (15, 30, 60 min). The study found that the mortality of houseflies on exposure to Averrhoa bilimbi leaf extract (67.25), Catharanthus roseus (86.75), soursop (97.25). The treatments showed a significant effect on mortality (P < 0.05), with the highest level of effectiveness at a dose of 25%, for 15 min. Flavonoids are believed to be the compounds responsible for the death of flies.