Kombinierte Nieren-Pankreas-Transplantation

Schäffer, Michael; Bartmann, V.; Wünsch, Andreas; Traska, T; Schenker, Peter; Michalski, Stefan G.; Viebahn, Richard

doi:10.1007/s00104-007-1362-0

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…When analyzing donor-specific factors, no significant difference was found between patients receiving an organ from a male donor or a female donor. This is in contrast to a recent contribution by Schäffer et al [14] who reported significant differences correlated with sex, but this contribution focused on long-term survival and graft function and did not specifically analyze postoperative complications. In accordance with other authors [9,10], donor age significantly affected the prevalence of pancreasrelated complications, as well as the prevalence of complications with interventions.…”

Section: Discussioncontrasting

confidence: 74%

“…The mean age of donors was 34.1 years (range, 11-58 years). Based on a recent publication [11], the donors had a mean "preprocurement pancreas allocation suitability score (P-PASS) of 14 (range, [9][10][11][12][13][14][15][16][17][18][19]. The mean length of stay of the recipient in hospital starting with the transplantation and ending with the first discharge was 55 days (range, 21-219 days).…”

Section: Patientsmentioning

confidence: 99%

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Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas–kidney transplantation

Fellmer

Pascher

Kahl

et al. 2009

Langenbecks Arch Surg

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Early postoperative complications after combined pancreas-kidney transplantation have a considerable effect on short- and long-term outcomes. Several statistically relevant factors related to pancreas- or surgery-associated complications could be identified. These data may help to improve early outcome after SPK by consideration of relevant risk factors when choosing an organ and a recipient for transplantation.

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Section: Discussioncontrasting

confidence: 74%

Section: Patientsmentioning

confidence: 99%

Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas–kidney transplantation

Fellmer

Pascher

Kahl

et al. 2009

Langenbecks Arch Surg

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“…Colling and colleagues reported that recipient sex affected outcome after pancreas transplantation, and that a higher prevalence of early (<6 months) PGF was observed in women 15 . Schaffer and colleagues found an increased risk of organ rejection in female donors after pancreas transplantation 17 . To optimize organ utilization due to the severe shortage of donors worldwide, donor-related factors have been studied widely for their impact on graft function.…”

Section: Discussionmentioning

confidence: 99%

“…However, all of these reports looked only at the impact of donor sex or recipient sex. Also, the results of studies analyzing the influence of associations between donor sex and recipient sex on PGS in small-sample cohorts or in single-center studies have been contradictory 13 14 15 16 17 .…”

mentioning

confidence: 99%

Influence of donor–recipient sex mismatch on long-term survival of pancreatic grafts

Mei

Xiang

et al. 2016

Sci Rep

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To assess the role of sex mismatch on graft survival after pancreas transplantation. We evaluated 24,195 pancreas-transplant recipients reported in the Scientific Registry of Transplant Recipients over a 25-year period. Pancreatic graft survival (PGS) was analyzed according to donor–recipient sex pairing using Kaplan–Meier estimations. Hazard ratios were estimated using Cox proportional hazard models. A total of 14,187 male and 10,008 female recipients were included in final analyses. Mean follow-up was 8.3 ± 5.7 years. In multivariate analyses, neither recipient sex nor donor sex was associated with pancreatic graft failure (PGF), but donor–recipient sex mismatch (regardless of recipient sex) was an independent predictor of PGS (HR, 1.09; 95% CI, 1.04–1.14; p < 0.001). Compared with M → M sex-matched recipients in univariate analyses, M → F and F → M sex mismatches were associated with an increased risk of PGF. Adjustment for significant recipient and donor factors eliminated the association between F → M sex mismatch and PGF (HR, 1.02; 95% CI, 0.93–1.10; p = 0.752), but not M → F (1.09; 1.02–1.17; 0.020). Stratified analyses suggested that the negative effect of donor–recipient sex mismatch could be neutralized in older patients. These findings suggest that donor–recipient sex pairing should be taken into consideration in organ-allocation strategies.

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“…Women had a greater risk for early graft failure compared to men after SPKT, caused by thrombosis and acute rejection at an earlier point in time. However, interestingly, the overall survival of pancreas grafts in women was similar to that in men [61,62]. Female recipients of male grafts currently have the best long-term outcome for renal and pancreatic graft function [62].…”

Section: Pancreas Transplantationmentioning

confidence: 99%

Gender Mainstreaming and Transplant Surgery

et al. 2016

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Background: Gender differences in medicine are gaining in importance. In transplant surgery, not only the patient's gender but also that of the donor play an important role in the outcome of transplantation due to sociocultural and genetic factors. Methods: This review article gives an overview of the latest investigations into gender-related influences in the field of visceral transplantation. For this purpose, a systematic review of the literature was performed. Results: In general, women are less often evaluated for and subjected to transplantation worldwide. Significantly poorer outcome can be observed in women with liver transplantation following hepatitis C cirrhosis. Furthermore, female renal grafts are less favorable in terms of outcome and survival. Gender disparities affect transplant medicine due to subtle gender-specific immunological factors. Sociocultural factors also lead to differences in the clinical treatment of men and women, which may influence overall survival. Conclusion: For a better understanding of gender-specific differences in transplant medicine and a possible improvement in outcome, further research in this field is necessary.

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Kombinierte Nieren-Pankreas-Transplantation

Abstract: This is the first report of graft function after simultaneous pancreas-kidney transplantation looking specifically at gender differences with respect to donor and recipient. There was an increased risk of organ rejection of female donor organs.

Cited by 6 publications

References 25 publications

Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas–kidney transplantation

Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas–kidney transplantation

Influence of donor–recipient sex mismatch on long-term survival of pancreatic grafts

Gender Mainstreaming and Transplant Surgery

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