Kombinierte Tiefenhyperthermie und Chemo- therapie mit 5-Fluorouracil/Natriumfolinat und Mitomycin bei vorbehandelten Patienten mit inoperablen kolorektalen Lebermetastasen − eine Fallstudie

Abstract

Einleitung Fortgeschrittene kolorektale Karzinome entwickeln in bis zu 50 % der Fälle Lebermetastasen. Bei einem kleineren Teil dieses Patientenkollektivs (15-20 %) kann durch eine R0-Resektion der Leberfiliae eine langfristige Kuration erreicht werden [13]. Das 5-Jahresüberleben liegt dann zwischen 20 und 45 % [5, 13]. In der Mehrzahl sind kolorektale Lebermetastasen je-

Systematic review about complementary medical hyperthermia in oncology

“…Period of time: November 2013–August 2014 n = 10. Colorectal cancer, hepatic metastasis Metastasis response: PD: n = 2, PR: n = 3, at 2 months: hepatic PD: n = 3, PD-free 3 months after treatment: n = 3, RR (PR and CR): 30% Sahinbas et al [ 84 ] EH (local electrohyperthermia) + CTx, 1 h, during first and second CTx-cycle three times a week. From third CTx-cycle two times a week.…”

“…Colorectal cancer, hepatic metastasis Local PFS at 3 months: 30%. Data from start of treatment Sahinbas et al [ 84 ] EH (local electrohyperthermia) + CTx, 1 h, during first and second CTx-cycle three times a week. From third CTx-cycle two times a week.…”

“…Metal stent in the canal or duct: no absolute contraindication for EH Further Wismeth et al [ 81 ] Reasons for patients, dose could not fully escalated: subjective overheating, headache, other signs of intracranial pressure. Didn’t reach minimum protocol dose: n = 2 (13%) Related to EH and/or CTx (no further distinction by the authors): Haematologic Sahinbas et al [ 84 ] Leucopenia: (grade 1): n = 1 (25%), (grade 2): n = 3 (75%). Thrombocytopenia: (grade 1): n = 2 (50%), (grade 2): n = 1 (25%), (grade 3): n = 1 (25%).…”

“…Anaemia: (grade 1): n = 1 (25%), (grade 2): n = 2 (50%), (grade 3): n = 1 (25%). Granulocytopenia: (grade 2): n = 3 (75%) Hepatic dysfunction Sahinbas et al [ 84 ] Bilirubin elevation: (grade 3): n = 1 (25%). GOT (glutamate oxaloacetate transaminase) elevation: (grade 1): n = 2 (50%), (grade 2): n = 1 (25%).…”

“…GPT (glutamate pyruvate transaminase) elevation: (grade 1): n = 3 (75%). AP (alkaline phosphatase) elevation: (grade 2): n = 2 (50%), (grade 3): n = 1 (25%) Gastro-intestinal Sahinbas et al [ 84 ] Nausea: (grade 1): n = 1 (25%) Gadaleta-Caldarola et al [ 80 ] Vomiting (grade 1 or 2): 10%, diarrhoea (grade 3): 5%, anorexia (grade 1 or 2): 25% Skin lesions Gadaleta-Caldarola et al [ 80 ] Hyperemia (grade 1 or 2): 20%, hand foot skin reaction (grade 3): 10% Alopecia Sahinbas et al [ 84 ] (grade 1): n = 1 (25%) Fatigue Gadaleta-Caldarola et al [ 80 ] (grade 3): 5% Hypertension Gadaleta-Caldarola et al [ 80 ] (grade 3): 5% Related to EH and/or RTx (no further distinction by the authors): Haematologic Heo et al [ 86 ] Anaemia: (grade 1): 5%, (grade 2): 30%. Leucopenia: (grade 1): 5%, (grade 2): 5% Gastro-intestinal Heo et al [ 86 ] Nausea: (grade 2): 15%.…”