Komplette Response nach neoadjuvanter Therapie beim Magenkarzinom: Implikationen für die Chirurgie

Capovilla, Giovanni; Froiio, Caterina; Lang, Hauke; Berlth, Felix; Grimminger, Peter

doi:10.1007/s00104-021-01516-4

Cited by 1 publication

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References 38 publications

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“…The resectability of esophageal and pancreatic tumors due to the preoperative oncological treatment has increased by approximately 20%. 3 , 4 Significantly increased rates of R0 resections have been reported in advanced gastric 5 , 6 and squamous esophageal cancer, 7 , 8 and significantly improved survival rates have been found in patients with esophageal, 9 gastric 10 , 11 and pancreatic cancers. 4 Based partly on our own, partly on others’experience, improvement in survival has been demonstrated in almost all gastrointestinal, lung and breast cancers.…”

Section: Introductionmentioning

confidence: 99%

Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments

Horváth,

Bellyei,

Pozsgai

et al. 2023

TCRM

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From a surgical point of view, the development of preoperative oncological treatment has had a profound effect on the surgical treatment trends of cancer as well as on the outcomes of cancer patients. Consequently, these changes have challenged formerly entrenched oncological surgical principles. In our short report, we aimed to summarize the main shifts regarding the surgical principles of cancer treatment due to the development of preoperative oncological therapy in recent years. As a result of successful preoperative treatment, surgeons may perform less radical surgeries, the required free resection margin has been narrowed down to a few millimeters in dimension and preoperative treatment is justified in both definitely resectable tumors and in oligometastatic tumors as well. For prognosis assessment, the post-preoperative oncological treatment stage is now considered decisive, rather than the pretreatment stage as previously thought. Other changes include the introduction of the watch and wait strategy and the reverse order of treatment of the primary tumor and metastasis. Observing the continuously improving outcomes of cancer patients and the developments in oncological treatment modalities, a further expansion of the indication of preoperative treatments is to be expected.

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