Konstitution des Aldosterons, des neuen Mineralocorticoids

Sa, Simpson; Jf, Tait; Wettstein, A.; Neher, R.; J, Von Euw; Schindler, O.; Reichstein, T.

doi:10.1007/bf02158515

Cited by 189 publications

(45 citation statements)

References 6 publications

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“…A c c e p t e d M a n u s c r i p t 3 Aldosterone, the endogenous mineralocorticoid in humans, was first isolated in 1953 as the last of the steroid hormones (Simpson et al, 1954). In the early years, the main focus of research lay on the long-term effects of aldosterone on sodium-potassium homeostasis and regulation of blood pressure in so called mineralocorticoid target organs like kidney, colon and salivary glands.…”

Section: Page 3 Of 28mentioning

confidence: 99%

New aspects of rapid aldosterone signaling

Großmann

Gekle

2009

Molecular and Cellular Endocrinology

118

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Section: Page 3 Of 28mentioning

confidence: 99%

New aspects of rapid aldosterone signaling

Großmann

Gekle

2009

Molecular and Cellular Endocrinology

118

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“…T he sodium homeostasis regulatory hormone aldosterone was first identified in 1953 (1). Early studies on the biochemical mechanism of its action were reviewed by Edelman and Fimognari (2).…”

mentioning

confidence: 99%

Aldosterone acts via an ATP autocrine/paracrine system: The Edelman ATP hypothesis revisited

Gorelik

Zhang

Sánchez

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Aldosterone, the most important sodium-retaining hormone, was first characterized >50 years ago. However, despite numerous studies including the classical work of Isidore S. ''Izzy'' Edelman showing that aldosterone action depended on ATP production, the mechanism by which it activates sodium reabsorption via the epithelial sodium channel remains unclear. Here, we report experiments that suggest that one of the key steps in aldosterone action is via an autocrine͞paracrine system. The hormone stimulates ATP release from the basolateral side of the target kidney cell. Prevention of ATP accumulation or its removal blocks aldosterone action. ATP then acts via a purinergic mechanism to produce contraction of small groups of adjacent epithelial cells. Patch clamping demonstrates that it is these contracted cells that have channel activity. With progressive recruitment of contracting cells, there is then a parallel increase in transepithelial electrical conductance. In common with other stimuli of sodium transport, this pathway involves phosphatidylinositol 3-kinase. Inhibition of phosphatidylinositol 3-kinase blocks both cell contraction and conductance. We put forward the hypothesis that redistribution of the cell volume caused by the lateral contraction results in apical swelling and that this change, in turn, disrupts the epithelial sodium channel interaction with the F-actin cytoskeleton, opening the channel and hence increasing sodium transport.scanning ion conductance microscopy ͉ scanning probe microscopy ͉ epithelial sodium channel ͉ renal epithelium T he sodium homeostasis regulatory hormone aldosterone was first identified in 1953 (1). Early studies on the biochemical mechanism of its action were reviewed by Edelman and Fimognari (2). This work was greatly helped by the introduction by Ussing and Zerahn (3) of the short-circuit current method for measuring sodium transport. Jean Crabbé (4, 5) first demonstrated the effect of aldosterone on sodium transport across toad bladder and skin and drew attention to the latent period of 60-90 min in the action of aldosterone. He postulated the synthesis or activation of an intermediate by aldosterone. Work by Edelman et al. (6) showed that inhibition of DNA-dependent RNA synthesis and of protein synthesis blocked the aldosterone effect. Edelman et al. (6) went on to demonstrate that aldosterone activation of sodium transport was critically dependent on ATP production. In substrate-depleted toad bladders, aldosterone had little or no effect, but the response was restored by adding glucose or pyruvate to the medium. Edelman suggested that a possible explanation of this absolute dependence on substrate was that, in the energy-depleted system, the rate of activation of sodium transport was limited by the local concentration of ATP. However, he felt that this hypothesis was questionable given that substrate-depleted toad bladders responded to vasopressin and to amphotericin B with a normal increase in sodium transport. This work became known as the ATP generation hypothe...

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“…In 1952 Tait et al [85] reported the sodiumretaining effect of an unidentified adrenal extract; and in 1953 Simpson et al [78] described the crystallization of this sub stance. Initially named sodium-retaining corticoid by Luetscher and co-workers [54,56] and electrocortin by Simpson et al [77], this hormone was renamed aldosterone when its structure was determined in 1954 [79].…”

Section: Early Studies: 1950-1956mentioning

confidence: 99%