Kontinenzleistung nach Therapie des Rektumkarzinoms

Schiffmann, Leif; Bath, Kristina; Wedermann, Nicole; Gock, Michael; Klar, E.

doi:10.1007/s00053-013-0405-x

Cited by 1 publication

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Introductionmentioning

confidence: 99%

“…Previously, we and other working groups have shown that neoadjuvant RCT (nRCT) leads to improved cancer-related survival and disease-free survival on the one hand, but also to more complications and potentially impaired function on the other. [1][2][3] Endoscopic vacuum therapy (EVT) has become the treatment of choice for anastomotic leaks after rectal resections in various institutions. Suction and drainage via an open-pored polyurethane sponge decrease bacterial contamination, secretion, and local edema.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neoadjuvant radio-chemotherapy prolongs healing of anastomotic leakage after rectal resection treated with endoscopic vacuum therapy

Schiffmann

Wedermann

Schwandner

et al. 2019

Therap Adv Gastroenterol

View full text Add to dashboard Cite

Background: Neoadjuvant radiochemotherapy (nRCT) is an important component in the treatment of advanced rectal cancer. Endoscopic vacuum therapy (EVT) has become the treatment of choice for anastomotic leakage after rectal resection in many institutions in Germany. Published case series report on average success and stoma reversal rates of more than 80%. However, so far, there is no distinct report on the potential influence of nRCT on EVT. Methods: A total of 11 patients treated with EVT for anastomotic leakage after nRCT and rectal resection were retrospectively compared with a cohort of eight patients with rectal anastomotic leakage without neoadjuvant treatment. Primary endpoints were death, treatment success, and long-term preservation of intestinal continuity. Secondary endpoint was the duration of treatment. Statistical analysis was performed using Statistical Package for Social Science (SPSS) version 23.0. Results: There was no difference in mortality (0%), success rate (90.9% versus 100%, p = 0.381), or long-term preservation of continuity (63.6% versus 62.5%, p = 0.960). After nRCT, patients showed a significant longer duration of EVT (31.1 days versus 15.9 days, p = 0.040) which was associated with a significantly higher number of sponge applications (9.6 versus 5.0, p = 0.042). Conclusions: In our analysis, EVT showed success in over 90% of patients with anastomotic leakage after rectal resection for colorectal cancer, regardless of neoadjuvant treatment. However, in case of anastomotic leakage, nRCT seems to be associated with the need for a significant longer duration of EVT.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%