Kontinuierliche 24-h-Aufzeichnung von Augendruckschwankungen mittels drahtlosem Kontaktlinsensensor Triggerfish™

Faschinger, C.; Mossböck, Georg

doi:10.1007/s00347-010-2198-4

Cited by 28 publications

(11 citation statements)

References 11 publications

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“…A similar implantable device also has been described for monkeys [35], and a less invasive prototype has been described for rabbits utilizing a 30 g needle in the vitreous cavity [36]. Recently, a telemetric contact lens sensor (SENSIMED Triggerfish ® ) has been used in humans to frequently measure IOP over a 24 h period [33,37]. This device has demonstrated that IOP is very dynamic and that measurements at just a few time points may not fully reflect the physiologic changes in IOP [33,37].…”

Section: Continuous Iop Measurementsmentioning

confidence: 97%

“…Recently, a telemetric contact lens sensor (SENSIMED Triggerfish ® ) has been used in humans to frequently measure IOP over a 24 h period [33,37]. This device has demonstrated that IOP is very dynamic and that measurements at just a few time points may not fully reflect the physiologic changes in IOP [33,37]. The device does not, however, measure IOP per se but instead measures relative changes in IOP in arbitrary units which cannot be easily translated into absolute IOP values [33,37].…”

Section: Continuous Iop Measurementsmentioning

confidence: 97%

“…Some researchers do this with the animal anesthetized (ketamine/xylazine) whereas others do not. Most investigators warm the water to 37 C to avoid substantial drops in body temperature (which can lead to a number of other potentially confounding physiologic alterations). IOP generally increases from approximately 15 mmHg at baseline to low 30's, peaking at 20-30 min after administration of the water bolus and lasting for 2-3 h. With this model the test article is typically given prior to water loading and IOP is measured at various intervals depending on the pharmacokinetics of the test article.…”

Section: Rabbit Models Of Ocular Hypertensionmentioning

confidence: 99%

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Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs

Miller

2013

Methods in Pharmacology and Toxicology

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A large number of factors are important in conducting anti-glaucoma drug efficacy studies. It is essential to have an understanding of aqueous humor dynamics and how the tonometer, tonometrist, and animal may affect IOP estimates. Additional critical considerations in the design of an anti-glaucoma drug efficacy studies include the following: (1) selecting the most appropriate species, (2) identifying the rate of nonresponders within the study population, (3) determining whether normotensive or glaucomatous animals should be used, and deciding (4) what secondary endpoints (if any) to include, and (5) whether one eye or both should be dosed. Anti-glaucoma drug efficacy studies have an acclimation phase in which the animal becomes conditioned to the procedures, a predose phase in which baseline data is collected, a dosing phase in which the drug is administered and IOP and possibly other endpoints are monitored, and a recovery phase in which IOP returns to predose values as the drug is washed out before another predose phase is started.

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Section: Continuous Iop Measurementsmentioning

confidence: 97%

Section: Continuous Iop Measurementsmentioning

confidence: 97%

Section: Rabbit Models Of Ocular Hypertensionmentioning

confidence: 99%

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Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs

Miller

2013

Methods in Pharmacology and Toxicology

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“…Die Sensorkontaktlinse Triggerfish (Sensimed, Lausanne, Schweiz) hat für Sicherheit und Verträglichkeit im Jahr 2009 eine CE-Zertifizierung erhalten. Diese beiden Parameter haben sich in einigen Studien als gut erwiesen [6][7][8][9][10]. De Smedt [10] beschrieb die Verträglichkeit der Kontaktlinse bei 10 Normalaugen, während bei den anderen Publikationen Patienten mit okulärer Hypertension und Glaukom eingeschlossen wurden.…”

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Validität und Reproduzierbarkeit von Sensorkontaktlinsen-Profilen im Vergleich zur Applanationstonometrie bei gesunden Augen

Faschinger

Mossböck

Krainz

2012

Klin Monatsbl Augenheilkd

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Intraocular pressure measurements gained by applanation tonometry showed the expected physiological positive slope profile during changes of the body and head positions (upright, supine, head-body-down). None of the profiles simultaneously gained by the sensor contact lens had a slope-like shape, but were flat or even downward. The reasons for the lacking validity between applanation tonometry and sensor contact lens cannot be explained. This makes the interpretation of Triggerfish profiles uncertain and they should therefore be done with caution. The reproducibility of the applanation tonometry values as well as of the sensor contact lens values was good and showed no significant differences.

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“…Dies wurde kürzlich durch Jonas [48] Zurzeit ist ein kontaktlinsengestützter Augendrucksensor in Entwicklung, der ein ambulantes 24-Stunden-Augeninnendruckprofil ermöglichen soll. Dies ist insofern von großem Interesse, da auch Augendruckwerte unter alltäglichen Belastungssituationen erfasst werden könnten [55]. Diese Technik ist derzeit in der Schweiz bereits auf dem Markt, in Deutschland erfolgen derzeit die Zulassungsstudien in ausgewählten Zentren.…”

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Physiologie der Kammerwasserproduktion sowie der Tagesdruckschwankungen und deren Bedeutung für das Glaukom

Göbel¹,

Rüfer²,

Erb³

2011

Klin Monatsbl Augenheilkd

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In the human eye there is a balance between production of aqueous humor as well as its drainage. The intraocular pressure is held through different mechanisms in a stable balance. The aqueous humor is secreted by the ciliary epithelium lining the ciliary processes. Three physiological processes contribute to the formation and chemical composition of the aqueous humor: diffusion (5 %), ultrafiltration (15 %) and active secretion (80 %). The normal intraocular pressure amounts to 15 ± 3 mmHg, the normal diurnal fluctuation 5 mmHg. Aqueous humor leaves the eye by passive bulk flow via two pathways: the trabecular route and the uveoscleral route. In glaucoma patients this balance is disturbed resulting in individual high intraocular pressure or, respectively, high diurnal fluctuations. This leads to loss of retinal ganglion cells and visual field loss. As a recommendation for glaucoma patients it is useful to construct diurnal intraocular pressure curves to evaluate the "type of pressure" and to determine the diurnal fluctuations or, respectively, the time of the pressure maxima. With this knowledge, treatment of glaucoma patients can be managed in a more individualised manner and it seems to slow down the progress of the disease better than by merely reducing the intraocular pressure.

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Kontinuierliche 24-h-Aufzeichnung von Augendruckschwankungen mittels drahtlosem Kontaktlinsensensor Triggerfish™

Cited by 28 publications

References 11 publications

Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs

Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs

Validität und Reproduzierbarkeit von Sensorkontaktlinsen-Profilen im Vergleich zur Applanationstonometrie bei gesunden Augen

Physiologie der Kammerwasserproduktion sowie der Tagesdruckschwankungen und deren Bedeutung für das Glaukom

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