This study was aimed to determine serum amyloid-a (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) levels in dogs infected with Sarcoptes canis. The animal material of the study was consisted of 25 dogs with different age, gender and race (13 female, 12 male) which were bearing symptoms such as itching, rash and crusting and were diagnosed as Sarcoptes canis in the clinics of Internal Medicine Department of Veterinary Faculty, Kafkas University. 10 healthy dogs of different age, sex and race (4 female, 6 male) were used for the control group. Biochemical analysis revealed that the SAA and Hp values of the sick animals were statistically different than healthy animals (P<0.001). Similarly, when the serum Cp values of sick animals were compared with those of healthy animals, the difference was statistically significant (P<0.05). Obtained results showed that investigated acute phase proteins were found increased in dogs with Sarcoptes canis with local skin damage. It was concluded that acute phase proteins, SAA, Hp and Cp can be used as inflammatory indicators in sarcoptic mange in dogs.