Kopolimerisasi Cangkok Poli(kaliumakrilat)- Gelatin Hasil Iradiasi Gamma

Abstract

KOPOLIMERISASI CANGKOK POLI(KALIUMAKRILAT)-GELATIN HASIL IRADIASI GAMMA. Hidrogel Super Absorben (HSA) merupakan polimer yang dapat menyerap air dalam jumlah yang relatif besar (± 1000 kali berat kering) dan salah satu baku penting khususnya untuk popok bayi/dewasa. Satu seri HSA dibuat dari asam akrilat yang telah dinetralkan sebagian dengan KOH, lalu dicangkokan (grafting) dengan gelatin pada konsentrasi 1% hingga 4 %(b/v,%) dan diiradiasi menggunakan sinar gamma pada dosis tunggal 10 kGy (laju dosis 2,5 kGy/jam). Terjadi cangkok gelatin pada polimer diukur menggunakan Fourier Transform Infra Red (FT-IR) dan morfologi diobservasi menggunakan Scanning Electron Microscope (SEM). Fraksi gel dan kemampuan hidrogel dalam mempertahankan air yang diserap (rasio swelling) dan Equilibrium Degree of Swelling (EDS) hidrogel ditentukan dengan metode gravimetri. Hasil evaluasi menggunakan SEM, morfologi permukaan HSA hasil iradiasi menunjukkan terjadi cangkok polimer (kalium akrilat) pada molekul gelatin dan hasil pengukuran spektrum FT-IR menunjukkan gugus karboksilat (COOH) yang bereaksi dengan gelatin. Meningkatnya konsentrasi gelatin hingga 4 %, rasio swelling, fraksi dan EDS hidrogel juga mengalami peningkatan. Hidrogel HSA poli (kalium akrilat-g-gelatin dapat dipertimbangkan sebagai bahan material kandidat biodegradable hidrogel untuk aplikasi di biang kesehatan/farmasi.

Valorization of emperor fish (Lethrinus lentjan) skin for collagen isolation: effect of acetic acid ratio and extraction time

“…The absorption peak of amide A was identified at a wave number of 3367 cm -1 . According to [38] the absorption peak area of amide A is generally in the range of values from 3350-3550 cm -1 with the characteristics of stretch in NH group. If the NH group then binds to hydrogen bonds, the wave number of the absorption peak is lower at 3300 cm -1 [40].…”

Synthesis of Polyvinyl Alcohol (PVA)-Gelatin Hydrogel from White Snapper (Lates calcarifer, Bloch) with Gamma Irradiation and Its Characterizations

“…Matrix hydrogels were then melted (thawed) at room temperature for 6 hours; this step was repeated two more times. Hydrogel matrixes were gamma-irradiated at doses of 10 and 20 kGy [11,14,16].…”

“…White snapper (Lates calcarifer) is a species of fish consumed by Indonesians. Its waste can be used as a source for gelatin preparation [5]. Gelatin is non-toxic, biodegradable, and biocompatible in a physiological environment and could accelerate the growth of new cells [6][7][8].…”

“…At this time, the second type of source energy utilized for the bonding process is polymer/monomer crosslinking and degradation. Gamma and electron beam irradiation are superior to other methods in that, among others, they are fast, they generate no residues, and their irradiation doses can be set following the needs [14].…”

In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation

“…However, the crosslinker is toxic. One method that is promising, safe, and inexpensive to modify gelatin into hydrogel is to form a physical crosslinking through the freeze-thaw process which is blended with polyvinyl alcohol (PVA) polymers [21] or by combined freezing-thawing and gamma ray irradiation [22,23].…”