As most adoption studies have focused on adopted children and their vulnerability, with scant research on adult adoptees’ outcomes, the aim of the present study was to compare adult adoptees and nonadoptees on their experiences as parents and to explore more deeply the question of the role among adoptees of the conjugal relationship in the context of parenthood. A total of 268 adoptees matched one to one with 268 nonadoptees responded to several standardized scales (attachment, mental health, resilience, motivations for parenthood, parental stress, dyadic coping, and coparenting). The groups did not differ on the experience of parenthood, thus contradicting most previous studies. They did, however, differ on attachment, mental health and dyadic coping, with adoptees achieving lower scores. Only in the case of adoptees was dyadic coping found to have a mediating role on the relations between psychological characteristics and parental stress. Thanks to our efforts to make our samples as representative as possible, this study sheds new light on adoptees’ experience of parenthood, especially after the birth of their first child. Moreover, it presents adoptees from the perspective of resilience and offers new insights into their functioning as parents. It opens up both theoretical and clinical perspectives.