2003
DOI: 10.1046/j.1525-1594.2003.07173.x
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Korean Artificial Heart (AnyHeart): An Experimental Study and the First Human Application

Abstract: A Korean artificial heart (AnyHeart) has been implanted in 29 various animals (52-470 kg) to evaluate hemodynamic performance and electromechanical stability. Most were implantable biventricular assist devices in use. A right thoracotomy approach has been a standard technique of implantation. A preclinical fitting test was also performed to observe anatomical feasibility and to compare surgical techniques in 10 human cadavers. The first case of human application was made as a lifesaving procedure on June 12, 2… Show more

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Cited by 12 publications
(9 citation statements)
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“…ACT has always been used to monitor the anticoagulation effect of heparin in animal models, but the target is slightly different in previous studies, ranging from 1.2 to 2.0 times as baseline . In the present study, the target of 1.5–2.0 times as baseline could meet the requirement of anticoagulation and there were nether bleeding nor thrombosis during the whole process.…”
Section: Discussionmentioning
confidence: 61%
“…ACT has always been used to monitor the anticoagulation effect of heparin in animal models, but the target is slightly different in previous studies, ranging from 1.2 to 2.0 times as baseline . In the present study, the target of 1.5–2.0 times as baseline could meet the requirement of anticoagulation and there were nether bleeding nor thrombosis during the whole process.…”
Section: Discussionmentioning
confidence: 61%
“…Heparin levels are usually monitored using activated clotting time (ACT) or activated partial prothrombin time (aPTT); however, most investigators prefer using ACT to monitor the effects of heparin. The preferred postoperative ACT range differs among investigators, varying from 150 to 300 s or 1.2–2 times baseline (12,19,20), independent of the animal used (8–10,12,19). Because the ACT measurement is cheaper, faster, and easier to monitor, only a few investigators used aPTT to monitor the heparin effect (20,21).…”
Section: Anticoagulation Agentsmentioning
confidence: 99%
“…The preferred postoperative ACT range differs among investigators, varying from 150 to 300 s or 1.2–2 times baseline (12,19,20), independent of the animal used (8–10,12,19). Because the ACT measurement is cheaper, faster, and easier to monitor, only a few investigators used aPTT to monitor the heparin effect (20,21). It is generally accepted that aPTT measurement is more accurate than ACT measurement to evaluate the heparin effect (22,23).…”
Section: Anticoagulation Agentsmentioning
confidence: 99%
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“…Kyoung Sun et al of Korea University (Seoul, Korea) described in an update their artificial heart that is in clinical trials. Their first human trial was made in June 2001 (4).…”
Section: Artificial Hearts Ventricular Assist Devices and Rotary Blmentioning
confidence: 99%