Korean Gastric Cancer Association Nationwide Survey on Gastric Cancer in 2014

Eom, Bang Wool; 안혜성,; 이인섭,; Min, Jae-Seok; Gil, Son Young; Lee, Sang Eok; 김지훈,; Lee, Se-Youl; Kim, Joo Hang; Ahn, Sang-Hoon; Kim, Hyung‐Ho; Youngwoo, Kim

doi:10.5230/jgc.2016.16.3.131

Cited by 160 publications

(75 citation statements)

References 18 publications

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“…According to the results of this study, the detection rate of early GC (T1) has increased each year among the three phases, from 3.9% in Phase 1 to 14.4% in Phase 3 ( P = 0.000), which is partly attributed to accurate diagnostic methods, equipment support, and people’s strengthening of the concept of early diagnosis and early treatment. This is similar to the results of studies in Western countries[ 13 ] but still far from the respective 61% and 58% diagnostic rates reported by South Korea and Japan, which have already conducted early GC screening programs[ 40 , 41 ]. In this study, open surgery was one of the criteria, and the study did not include patients who underwent endoscopic resection (such as endoscopic mucosal resection and endoscopic submucosal dissection).…”

Section: Discussionsupporting

confidence: 88%

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

Zhai

Zhu

Cong

et al. 2020

WJGO

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BACKGROUND Through analyzing the data from a single institution in Northeast China, this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer (GC). AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China, which is a high-prevalence area of GC. METHODS The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer Hospital. The study mainly analyzed the data in three periods, 2000 to 2004 (Phase 1), 2005 to 2009 (Phase 2), and 2010 to 2014 (Phase 3). RESULTS Over time, the postoperative survival rate significantly increased from 2000 to 2014. In the past 15 years, compared with Phases 1 and 2, the tumor size was smaller in Phase 3 ( P < 0.001), but the proportion of high-medium differentiated tumors increased ( P < 0.001). The proportion of early GC gradually increased from 3.9% to 14.4% ( P < 0.001). A surprising improvement was observed in the mean number of retrieved lymph nodes, ranging from 11.4 to 27.5 ( P < 0.001). The overall 5-year survival rate increased from 24% in Phase 1 to 43.8% in Phase 3. Through multivariate analysis, it was found that age, tumor size, histologic type, tumor-node-metastasis stage, depth of invasion, lymph node metastasis, surgical approach, local infiltration, radical extent, number of retrieved lymph nodes, and age group were independent risk factors that influenced the prognosis of patients with GC. CONCLUSION The clinical features of GC in Northeast China changed during the observation period. The increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.

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Section: Discussionsupporting

confidence: 88%

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

Zhai

Zhu

Cong

et al. 2020

WJGO

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“…In Fareast Asia, including Korea and Japan, a higher proportion of EGC has been commonly detected in routine clinical. [ 48 , 49 ] Among those 27 included studies, we specially screened 8 EGC studies and found the pooled sensitivity was more frustrating: 0.34 (95% CI: 0.15–0.61). Fujikawa et al [ 27 ] reported the sensitivity was barely 0.04 (2/47) in clinical T1 staged GC in Japan.…”

Section: Discussionmentioning

confidence: 99%

Value and impact factors of multidetector computed tomography in diagnosis of preoperative lymph node metastasis in gastric cancer

Luo

Guo

et al. 2017

Medicine

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Background:Multidetector computed tomography (MDCT) exhibited wide ranges of sensitivities and specificities for lymph node assessment of gastric cancer (GC) in several individual studies. This present meta-analysis was carried out to evaluate the value of MDCT in diagnosis of preoperative lymph node metastasis (LNM) and to explore the impact factors that might explain the heterogeneity of its diagnostic accuracy in GC.Methods:A comprehensive search was conducted to collect all the relevant studies about the value of MDCT in assessing LNM of GC within the PubMed, Cochrane library and Embase databases up to Feb 2, 2016. Two investigators independently screened the studies, extracted data, and evaluated the quality of included studies. The sensitivity, specificity, and area under ROC curve (AUC) were pooled to estimate the overall accuracy of MDCT. Meta-regression and subgroup analysis were carried out to identify the possible factors influencing the heterogeneity of the accuracy.Results:A total of 27 studies with 6519 subjects were finally included. Overall, the pooled sensitivity, specificity, and AUC were 0.67 (95% CI: 0.56–0.77), 0.86 (95% CI: 0.81–0.90), and 0.86 (95% CI: 0.83–0.89), respectively. Meta-regression revealed that MDCT section thickness, proportion of serosal invasion, and publication year were the main significant impact factors in sensitivity, and MDCT section thickness, multiplanar reformation (MPR), and reference standard were the main significant impact factors in specificity. After the included studies were divided into 2 groups (Group A: studies with proportion of serosa-invasive GC subjects ≥50%; Group B: studies with proportion of serosa-invasive GC subjects <50%), the pooled sensitivity in Group A was significantly higher than in Group B (0.84 [95% CI: 0.75–0.90] vs 0.55 [95% CI: 0.41–0.68], P < .01). For early gastric cancer (EGC), the pooled sensitivity, specificity, and AUC were 0.34 (95% CI: 0.15–0.61), 0.91 (95% CI: 0.84–0.95), and 0.83 (95% CI: 0.80–0.86), respectively.Conclusion:To summarize, MDCT tends to be adequate to assess preoperative LNM in serosa-invasive GC, but insufficient for non-serosa-invasive GC (particularly for EGC) owing to its low sensitivity. Proportion of serosa-invasive GC subjects, MDCT section thickness, MPR, and reference standard are the main factors influencing its diagnostic accuracy.

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“…Laparoscopic gastrectomy for gastric carcinoma yields better early postoperative outcomes including lesser pain, fewer wound complications, shorter hospital stays, and improved short-term quality of life than open surgery [ 1 2 ]. In Korea and Japan, early gastric carcinoma now accounts for nearly 50% of all gastric cancer cases, and laparoscopic gastrectomy is widely performed as a minimally invasive treatment [ 3 4 ]. The surgical techniques of laparoscopic distal gastrectomy, including gastric resection and lymph node dissection, are relatively well-standardized among gastric surgeons.…”

Section: Introductionmentioning

confidence: 99%

“…With the rise in the aging population, the proportion of elderly patients who undergo gastric resection is continuously increasing. According to a Korean nationwide survey, the proportion of patients aged ≥70 years undergoing gastric cancer surgery has markedly increased from 9.1% to 25.3% in 1995 and 2014, respectively [ 3 ]. With increasing age, patients demonstrate a greater number of comorbidities such as hypertension, diabetes mellitus, and cardiovascular and pulmonary diseases.…”

Section: Introductionmentioning

confidence: 99%

Impact of Various Types of Comorbidities on the Outcomes of Laparoscopic Total Gastrectomy in Patients with Gastric Carcinoma

2018

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PurposeWith increasing life expectancy, the presence of comorbidities has become a major concern in elderly patients who require surgery. However, little is known about the impact of different comorbidities on the outcomes of laparoscopic total gastrectomy (LTG). In this study, we investigated the impact of comorbidities on postoperative complications in patients undergoing LTG for gastric carcinoma.Materials and MethodsWe retrospectively reviewed the cases of 303 consecutive patients who underwent LTG for gastric carcinoma between 2005 and 2016. The associations between each comorbidity and postoperative complications were assessed using univariate and multivariate analyses.ResultsA total of 189 patients (62.4%) had one or more comorbidities. Hypertension was the most common comorbidity (37.0%), followed by diabetes mellitus (17.8%), chronic viral hepatitis (2.6%), liver cirrhosis (2.6%), and pulmonary (27.1%), ischemic heart (3.3%), and cerebrovascular diseases (2.3%). The overall postoperative morbidity and mortality rates were 20.1% and 1.0%, respectively. Patients with pulmonary disease significantly showed higher complication rates than those without comorbidities (32.9% vs. 14.9%, respectively, P=0.003); patient with other comorbidities showed no significant difference in the incidence of LTG-related complications. During univariate and multivariate analyses, pulmonary disease was found to be an independent predictive factor for postoperative complications (odds ratio, 2.14; 95% confidence interval, 1.03–4.64), along with old age and intraoperative bleeding.ConclusionsAmong the various comorbidities investigated, patients with pulmonary disease had a significantly higher risk of postoperative complications after LTG. Proper perioperative care for optimizing pulmonary function may be required for patients with pulmonary disease.

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Korean Gastric Cancer Association Nationwide Survey on Gastric Cancer in 2014

Cited by 160 publications

References 18 publications

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

Value and impact factors of multidetector computed tomography in diagnosis of preoperative lymph node metastasis in gastric cancer

Impact of Various Types of Comorbidities on the Outcomes of Laparoscopic Total Gastrectomy in Patients with Gastric Carcinoma

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