Korean Herbal Medicine for Treating Henoch-Schonlein Purpura with Yin Deficiency: Five Case Reports

Kim, Sung Kyung; Ryu, Seung-Seon; Park, Sunju; Park, Sang-Kyun; Choi, Woo-Jin; Sun, Seung‐Ho

doi:10.3831/kpi.2014.17.040

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Furthermore, a number of studies on the effects of Yukmijihwang decoction have been conducted recently. Yukmijihwang decoction has been reported to be able to protect against β -amyloid toxicity [13], inhibit the development of benign prostatic hyperplasia [14], decrease proteinuria and protect kidney function [15], and lower body weight and improve insulin and leptin sensitivity in obese rats [16]; it can also be used to treat Henoch-Schonlein purpura caused by SEH [17]. …”

Section: Discussionmentioning

confidence: 99%

Study on the Single Dose Toxicity of ShinEumHur Pharmacopuncture Injected into the Muscles of Rats

Jeong

Cha

Lee

et al. 2016

Journal of Pharmacopuncture

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Objectives:This study was carried out to analyze the single dose toxicity of ShinEumHur (SEH) pharmacopuncture injected into the muscles of Sprague-Dawley rats.Methods:The SEH pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (K-GMP). After the mixing process with sterile distilled water had been completed, the pH was controlled to between 7.0 and 7.5. All experiments were conducted at Biotoxtech, an institution authorized to perform non-clinical studies under the Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen for the pilot study. Doses of SEH pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. We examined the survival rate, weights, clinical signs, mean hematology parameters, mean clinical chemistry, necropsy and histopathological findings.This study was conducted under the approval of the Institutional Animal Ethics Committee.Results:No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues.Conclusion:The above findings suggest that treatment with SEH pharmacopuncture is relatively safe. Further studies on this subject are needed to yield more concrete evidence.

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