Korean Observational Study Network for Arthritis (KORONA): Establishment of a Prospective Multicenter Cohort for Rheumatoid Arthritis in South Korea

Sung, Yoon‐Kyoung; Cho, Soo-Kyung; Choi, Chan-Bum; Park, So‐Yeon; Shim, Jina; Ahn, Joong Kyong; Bang, So-Young; Cha, Hoon‐Suk; Choe, Jung‐Yoon; Chung, Won Tae; Her, Minyoung; Hong, Seung‐Jae; Hong, Yun Kyung; Joung, Chung-Il; Jun, Jae‐Bum; Jung, Young Ok; Kang, Young Mo; Kim, Dongyook; Kim, Hae-Rim; Kim, Hyoun‐Ah; Kim, Jinseok; Kim, Seong-Kyu; Kim, Sung-Il; Kim, Tae‐Hwan; Kim, Tae‐Jong; Koh, Eun‐Mi; Lee, Choong‐Ki; Lee, Hye‐Soon; Lee, Sang Hoon; Lee, Sang‐Heon; Lee, Sanghoon; Lee, Shin-Seok; Lee, Sung Won; Lee, Yeon-Ah; Nah, Seong‐Su; Park, Sunghoon; Sheen, Dong‐Hoon; Shim, Seung-Cheol; Song, Gwan Gyu; Suh, Chang‐Hee; Uhm, Wan-Sik; Yoo, Dae-Hyun; Yoo, Wan‐Hee; Yoon, Bo Young; Bae, Sang‐Cheol

doi:10.1016/j.semarthrit.2011.09.007

Cited by 57 publications

(45 citation statements)

References 8 publications

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“…If anti-CCP negative RA is heterogeneous, it is possible that the make-up of this group differs between study populations, explaining the discrepant associations with the SE and smoking. The high anti-CCP antibody positivity we observed, although not different from that seen in the Korean Observational Study Network for Arthritis,49 may reflect it being a hospital-based cohort and so biased towards more severe disease.…”

Section: Discussioncontrasting

confidence: 70%

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

et al. 2013

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Section: Discussioncontrasting

confidence: 70%

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

et al. 2013

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“…A limitation of our study is that the number of individuals was large, but the numbers of smokers or those bearing the *04:05/*09:01 heterozygote among controls were very small. The prevalence of anti-CCP-positive RA in our cohort (86.3%; 1420/1645) was higher than that observed in other studies, but was similar to that seen in the Korean Observational Study Network for Arthritis (86.8%; 4098/4719) 40 , a prospective multicenter cohort for RA.…”

Section: Rheumatologysupporting

confidence: 84%

Interaction of HLA-DRB109:01 and 04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope

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Lee³

et al. 2013

J Rheumatol

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HLA-DRB1*09:01 differs from SE alleles with regard to anti-CCP levels and interaction with smoking, suggesting a distinct mechanism of HLA-DRB1*09:01 in the pathogenesis of RA that may bypass anti-CCP formation. Also, a significant increase of the HLA-DRB1*04:05/ *09:01 heterozygote in RA susceptibility may be attributable to the synergistic contribution of 2 different pathways in which 2 alleles participate independently.

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“…Patients were followed up annually and completed questionnaires to establish their demographic profiles, socio-economic statuses, and disease-specific outcomes. Further details of the study have been provided elsewhere (13). A total of 3,209 patients with RA were recruited.…”

Section: Methodsmentioning

confidence: 99%

Factors Contributing to Discordance between the 2011 ACR/EULAR Criteria and Physician Clinical Judgment for the Identification of Remission in Patients with Rheumatoid Arthritis

et al. 2016

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Remission is a primary end point of in clinical practice and trials of treatments for rheumatoid arthritis (RA). The 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria were developed to provide a consensus definition of remission. This study aimed to assess the concordance between the new remission criteria and the physician’s clinical judgment of remission and also to identify factors that affect the discordance between these two approaches. A total of 3,209 patients with RA were included from the KORean Observational Study Network for Arthritis (KORONA) database. The frequency of remission was evaluated based on each approach. The agreement between the results was estimated by Cohen’s kappa (κ). Patients with remission according to the 2011 ACR/EULAR criteria (i.e. the Boolean criteria) and/or physician judgment (n = 855) were divided into three groups: concordant remission, the Boolean criteria only, and physician judgment only. Multinomial logistic regression analysis was used to identify factors responsible for the assignment of patients with remission to one of the discordant groups rather than the concordant group. The remission rates using the Boolean criteria and physician judgment were 10.5% and 19.9%, respectively. The agreement between two approaches for remission was low (κ = 0.226) and the concordant remission rate was only 5.5% (n = 177). Pain affected classification in both discordant groups, whereas fatigue was associated with remission only by physician clinical judgment. The Boolean criteria were more stringent than clinical judgment. Patient subjective symptoms such as pain and fatigue were associated with discordance between the two approaches.

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Korean Observational Study Network for Arthritis (KORONA): Establishment of a Prospective Multicenter Cohort for Rheumatoid Arthritis in South Korea

Cited by 57 publications

References 8 publications

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

Interaction of HLA-DRB109:01 and 04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope

Factors Contributing to Discordance between the 2011 ACR/EULAR Criteria and Physician Clinical Judgment for the Identification of Remission in Patients with Rheumatoid Arthritis

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Korean Observational Study Network for Arthritis (KORONA): Establishment of a Prospective Multicenter Cohort for Rheumatoid Arthritis in South Korea

Cited by 57 publications

References 8 publications

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

Interaction of HLA-DRB1*09:01 and *04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope

Factors Contributing to Discordance between the 2011 ACR/EULAR Criteria and Physician Clinical Judgment for the Identification of Remission in Patients with Rheumatoid Arthritis

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Interaction of HLA-DRB109:01 and 04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope