Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses

Cha, Kyu-Min; Kopalli, Spandana Rajendra; Han, Sang Yun; Lee, Sang-Ho; Jeong, Manbok; Cho, Jae Youl; Han, Chang-Gyun; Lee, Seungho; Kim, Soo-Nam; Kim, Jin‐Chul; Kim, Si-Kwan

doi:10.1016/j.jff.2017.12.008

Cited by 14 publications

(10 citation statements)

References 40 publications

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“…However, curcumin was more effective than CAPE in terms of its effects on these parameters. Cha et al (2018) found that DOX significantly increased IL-1β and IL-6 levels from proinflammatory cytokines in a study on DOX-induced testicular dysfunction in rats. Polegato et al (2015) demonstrated that DOX partially reduced IL-10 levels from anti-inflammatory cytokines in the DOX-induced cardiotoxicity study.…”

Section: Discussionmentioning

confidence: 97%

“…For example, IL-1β has been reported to contribute to DOXinduced increase in IL-6 and granulocyte colony-stimulation factor (GCSF) levels and plays an important role in DOX-induced acute toxicity(Benzer et al, 2018) Russo et al (2018). showed that curcumin decreased IL-6 levels in people with chronic kidney disease Cha et al (2018). found that DOX significantly increased IL-1β and IL-6 levels from proinflammatory cytokines in a study on DOX-induced testicular dysfunction in rats Polegato et al (2015).…”

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confidence: 99%

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Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

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Testicular dysfunction is one of the serious side effects of cytotoxic chemotherapy. It has been reported that low sexual function and quality of life and infertility concerns associated with gonadal insufficiency in young patients are related to psychosocial distress (Levi et al., 2015). Doxorubicin (DOX, brand name Adriamycin), which is one of the most important cornerstones of many chemotherapeutic protocols, is an anticancer drug selected in the treatment of many chemo-responsive tumours from ovarian, breast, liver and lung cancer and lymphomas. However, DOX can cause severe dose-dependent toxicity for other nontarget tissues, including testicular tissues (e.g. reduced testicular weight; Nishi et al., 2018). Studies have reported that DOX toxicity causes testicular damage and apoptosis and adversely affects reproductive function (Kopalli et al., 2016; Nowrouzi et al., 2019). In addition, DOX has been reported to increase oxidative stress by reducing antioxidant capacity in testicular tissue (Uyeturk et al., 2014). Does DOX cause testicular toxicity by only increasing oxidative stress and apoptosis? Or does DOX have an effect on testicular

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Section: Discussionmentioning

confidence: 97%

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confidence: 99%

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

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“…Moreover, Cha et al [20] reported similar results in rat testis following doxorubicin treatment. These results match the results of our study where HFrD was found to downregulate Beclin-1 immunostaining.…”

Section: Discussionmentioning

confidence: 67%

Effect of high-fructose diet-induced metabolic syndrome on the pituitary-gonadal axis from adolescence through adulthood in male albino rats and the possible protective role of ginger extract. A biochemical, histological and immunohistochemical study

El-Mehi

Faried

2020

Folia Morphol

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Background: This work was designed to clarify, for the first time up to our knowledge, the effects of high fructose diet (HFrD) induced metabolic syndrome (MetS) on the pituitarygonadal axis of adolescent male rats continuing through adulthood period and to evaluate the possible role of ginger extract in ameliorating these effects. Materials and methods:Forty 4-week-old male albino rats, treated for 8 weeks, were randomly divided into 4 equal groups; control(fed standard diet), ginger extract treated (500 mg/kg once daily orally by gavage), HFrD induced MetS (fed a diet containing 60% fructose), HFrD and ginger groups. The assessment methods included biochemical, histological and immunohistochemical studies.Results: HFrD fed rats exhibited a picture similar to MetS in the form of increased body weight and serum levels of glucose and insulin with an elevated HOMA-IR reflecting insulin resistance as well as dyslipidemia. Lipid peroxidation (increased MDA) and oxidative stress (decreased SOD) were implicated in this syndrome. This group exhibited a significant decrease of testicular weight and the levels of reproductive hormones (LH, FSH & testosterone). The pituitary gonadotrophs showed electron dense nuclei, large cytoplasmic vacuoles, destructed organelles in addition to decreased number of secretory granules. Furthermore, testicular specimens presented marked alterations. There were disorganized shrunken tubules with irregular basement membranes, reduced germinal epithelial thickness, vacuolations and degenerated mitochondria in the spermatogenic cells.Beclin1 and PCNA immunoexpressions were significantly downregulated with HFrD induced MetS. Ginger extract supplementation proved to be a potent protective agent against these harmful effects through its antioxidant, hypoglycemic, insulinotropic, androgenic and hypolipidemic effects in addition to its ability to induce testicular autophagy. Conclusions: Consumption of HFrD induced MetS and proved to have harmful effects on the pituitarytesticular axis. Moreover, this work provided a new insight into the possible use of ginger extract to alleviate the main features of MetS and protect the pituitarygonadal axis from the damaging effects of HFrD induced MetS.

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“…Cha et al [35] reported that the extract had the potential to attenuate testicular dysfunction as treatment decreased molecules responsible for spermatogenesis and downregulated the mRNA levels of sex hormone receptors including the androgen, luteinizing hormone, and follicle-stimulating hormone receptors. Concomitantly, Korean Red Ginseng extract (RGE) also modulated autophagy responses by decreasing the mTORC1 mRNA and protein levels after they had been elevated by doxycycline (DOX)-induced testicular damage [35]. Nonetheless, further study is needed to determine the stage at which autophagy regulates testicular dysfunction and vice versa.…”

Section: Regulation Of Autophagy By Korean Ginseng Extractmentioning

confidence: 99%

“…Concomitantly, Korean Red Ginseng extract (RGE) also modulated autophagy responses by decreasing the mTORC1 mRNA and protein levels after they had been elevated by doxycycline (DOX)-induced testicular damage [35]. Nonetheless, further study is needed to determine the stage at which autophagy regulates testicular dysfunction and vice versa.…”

Section: Regulation Of Autophagy By Korean Ginseng Extractmentioning

confidence: 99%

Autophagy and its regulation by ginseng components

Qomaladewi

Kim

Cho

2019

Journal of Ginseng Research

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Autophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. In this review, we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we studied how its derivatives and metabolites can regulate autophagy and thus mediate the pathogenesis of certain diseases.

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Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses

Cited by 14 publications

References 40 publications

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Effect of high-fructose diet-induced metabolic syndrome on the pituitary-gonadal axis from adolescence through adulthood in male albino rats and the possible protective role of ginger extract. A biochemical, histological and immunohistochemical study

Autophagy and its regulation by ginseng components

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