Korean red ginseng extract does not cause embryo‐fetal death or abnormalities in mice

Shin, Sunhee; Jang, Ja Young; Park, Dongsun; Yon, Jung-Min; Baek, In-Jeoung; Hwang, Bang Yeon; Nam, Sang-Yoon; Yun, Young Won; Kim, Ki-Yon; Joo, Seong Soo; Kim, Yun-Bae

doi:10.1002/bdrb.20224

Cited by 23 publications

(21 citation statements)

References 31 publications

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“…Shin et al . [61] evaluated the toxicity of Korean red ginseng against embryonic implantation and mortality and fetal body weight gain at doses of up to 2,000 mg/kg/d, which is approximately 200 fold greater than the clinical dose recommended by the Korean Food and Drug Administration. The authors concluded that the consumption of ginseng did not cause embryo-fetal death or abnormalities.…”

Section: Summary Of the Major Findings Of Selected Publicationsmentioning

confidence: 99%

Trends in Ginseng Research in 2010

Kim¹,

Park²

2011

Journal of Ginseng Research

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A total of 470 papers directly related to research on the Panax species were retrieved by performing internet searches with the keywords Panax and ginseng as the search terms. The publications were categorized as follows: 399 research articles, 30 reviews, 30 meeting abstracts, 7 proceedings, and 4 letters. The majority of these publications were published by scientists from Korea (35.7%), China (32.3%), and the USA (11.3%). Scientists from a total of 29 nations were actively involved in conducting ginseng research. A total of 43.6% of the publications were categorized as pharmacodynamic studies. The effects of ginseng on cerebrovascular function and cancer were the two most common topics considered in the pharmacodynamic studies. More than half of the ginseng studies assessed the use of P. ginseng. A total of 23 countries participated in studies specifically related to P. ginseng, and more than 80% of these studies originated from Korea and China. A total of 50 topics within the pharmacodynamics category were examined in association with the use of P. ginseng.

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Section: Summary Of the Major Findings Of Selected Publicationsmentioning

confidence: 99%

Trends in Ginseng Research in 2010

Kim¹,

Park²

2011

Journal of Ginseng Research

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“…These negative in vitro outcomes with whole extracts contrast the findings from in vivo studies investigating the influence of Red Korean Ginseng treatment two weeks before mating and throughout gestation on pregnancy in the mouse (Shin et al, 2010). Due to these discrepancies in outcomes it was essential to conduct in vivo experiments using NAG on pregnancy and post-partum development in the mouse.…”

Section: Discussionmentioning

confidence: 90%

“…Conversely, Lee et al (2008) found treatment of early rat embryos with individual ginsenosides resulted in either no significant change to the morphological scores or improvements. In addition, very recent in vivo studies have shown that when up to 2000 mg/kg/day (≈200 times the recommended clinical dose) of Korean Red Ginseng extract was administered to female mice, maternal weight, feeding, embryonic implantation and fetal growth were not significantly affected (Shin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of American Ginseng on Preimplantation Development and Pregnancy in Mice

et al. 2016

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Abstract:In North America a high proportion of pregnant women use herbal medications, including North American ginseng. This medicinal plant contains a high amount of triterpene saponins (ginsenosides) which are the main bioactive compounds. It is important to assess ginseng's impact on all reproductive functions to ensure the safety of pregnant women and fetuses. In this study, we defined the concentration responsive effects of North American alcoholic and aqueous ginseng extracts on preimplantation development in vitro and on pregnancy and post-partum development in the mouse. Two-cell mouse embryos were cultured with 5 different concentrations of whole ginseng root extracts, or ginsenosides

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“…Several constituents of red ginseng have been reported to regulate proliferation and migration and to protect oxidative stress-mediated damage in human endothelial cells [38,39]. There is evidence demonstrating the presence of major ginsenosides including Rb1 and Rg1 in KRG water extract [40]. Thus, these components could also contribute to the diverse retinue of protective actions of KRG.…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells

Lee

Park

2014

Journal of Ginseng Research

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Cigarette smoke is considered a major risk factor for vascular diseases. There are many toxic compounds in cigarette smoke, including acrolein and other α,β-unsaturated aldehydes, which are regarded as mediators of inflammation and vascular dysfunction. Furthermore, recent studies have revealed that acrolein, an α,β-unsaturated aldehyde in cigarette smoke, induces inflammatory mediator expression, which is known to be related to vascular diseases. In this study, we investigated whether Korean Red Ginseng (KRG) water extract suppressed acrolein-induced cyclooxygenase (COX)-2 expression in human umbilical vein endothelial cells (HUVECs). Acrolein-induced COX-2 expression was accompanied by increased levels of phosphorylated p38 in HUVECs and KRG inhibited COX-2 expression in HUVECs. These results suggest that KRG suppresses acrolein-induced COX-2 expression via inhibition of the p38 mitogen-activated protein kinase signaling pathway. In addition, KRG exhibited an inhibitory effect on acrolein-induced apoptosis, as demonstrated by annexin V–propidium iodide staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay. Consistent with these results, KRG may exert a vasculoprotective effect through inhibition of COX-2 expression in acrolein-stimulated human endothelial cells.

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Korean red ginseng extract does not cause embryo‐fetal death or abnormalities in mice

Cited by 23 publications

References 31 publications

Trends in Ginseng Research in 2010

Trends in Ginseng Research in 2010

Effects of American Ginseng on Preimplantation Development and Pregnancy in Mice

Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells

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