Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Souza, Leanne R. De; Jenkins, Alexandra L.; Sievenpiper, John L.; Jovanovski, Elena; Rahelić, Dario; Vuksan, Vladimir

doi:10.1016/j.jep.2011.05.015

Cited by 28 publications

(25 citation statements)

References 37 publications

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“…7 De Souza et al reported differential effects of KRG root fractions on postprandial glycemia in healthy individuals. 8 Their study found…”

Section: Discussionmentioning

confidence: 94%

“…3 Until now, there have been few clinical studies on the efficacy of red ginseng extract or powder for blood glucose control, and past studies mostly included people with type 2 diabetes mellitus (T2DM) or normal blood glucose levels. [4][5][6][7][8][9] There has not been a clinical trial on the effect of Korean red ginseng on regulation of blood glucose in subjects with IFG, IGT, or newly diagnosed T2DM.…”

Section: Introductionmentioning

confidence: 99%

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Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Bang

Kwak

Ahn

et al. 2014

Journal of Medicinal Food

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This study was designed to evaluate the effect of Korean red ginseng (KRG) supplementation on glucose control in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes mellitus (T2DM). The study was a 12-week randomized, double-blinded, placebo-controlled (5 g of KRG [n = 21] or placebo [n = 20] in tablet form) trial. Glucose-related biomarkers, including serum and whole blood levels of glucose, insulin, and Cpeptide, were measured by 2-h oral glucose tolerance tests (OGTTs) at baseline and after the 12-week intervention. After the intervention, the test group showed a significant decrease in serum levels of glucose at 30 min ( -22.24 -10.77 mg/dL) and whole blood levels of glucose at 30 min ( -17.52 -5.22 mg/dL). In addition, the test group tended to have lower whole blood levels of glucose at 0 min and glucose area under curve (AUC). However, the placebo group did not show any changes in blood glucose-related indices. The changes (difference from baseline) in serum glucose levels at 30 min, whole blood glucose levels at 60 min, and glucose AUC during OGTTs in the test group exhibited a tendency toward a decrease from those in the placebo group. There were significant decreases or trends toward a decrease in both serum insulin and C-peptide concentrations at most time intervals in the test group. In conclusion, KRG supplementation (5 g/day) may be beneficial for controlling serum and whole blood glucose levels compared with placebo among patients with IFG, IGT, or T2DM.

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“…7 De Souza et al reported differential effects of KRG root fractions on postprandial glycemia in healthy individuals. 8 Their study found…”

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Bang

Kwak

Ahn

et al. 2014

Journal of Medicinal Food

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“…Meyer) at 98-100 1C for 2-3 h, has long been used as a traditional medicine in Korea to treat diabetes mellitus (The editing committee for the History of Korean Ginseng, 2001). KRG has been reported to have a hypoglycemic effect in type 2 diabetic animals (Franz et al, 2002;Kim et al, 2005;Liu et al, 2005;Lee et al, 2009) and humans Vuksan et al, 2003Vuksan et al, , 2006De Souza et al, 2011). KRG might mediate its hypoglycemic effect through a variety of mechanisms including actions on the insulin-secreting pancreatic b-cells and the target tissues that take up glucose.…”

Section: Introductionmentioning

confidence: 99%

Regulation of signaling molecules associated with insulin action, insulin secretion and pancreatic β-cell mass in the hypoglycemic effects of Korean red ginseng in Goto-Kakizaki rats

Kim

2012

Journal of Ethnopharmacology

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“…In one study with healthy volunteers, only a trend for hypoglycemic effects was found and one study did not find any effects of American ginseng on PPG (Sievenpiper et al, 2003a). The effects of Asian ginseng are mixed, with some studies showing increasing (Sievenpiper et al, 2003a), no (Sievenpiper et al, 2003a(Sievenpiper et al, , 2003bReay et al, 2006;Reay et al, 2009) or decreasing effects up to 29% (Sievenpiper et al, 2006;De Souza et al, 2011) on indices of PPG in healthy volunteers. The high variability in efficacy on PPG may be secondary to the variability in the ginseng source (species, batch, preparation, part of the plant, and variety) and its composition, as represented by the measured ginsenoside profile.…”

Section: Impact Of Phytochemicals On Blood Glucose Regulationmentioning

confidence: 98%

“…The high variability in efficacy on PPG may be secondary to the variability in the ginseng source (species, batch, preparation, part of the plant, and variety) and its composition, as represented by the measured ginsenoside profile. For example, Korean red ginseng rootlets have been shown to decrease PPG , while the root body has not (Sievenpiper et al, 2006;De Souza et al, 2011). This inconsistency limits the generalizability of the effects from one ginseng source to another and thereby, the use of ginseng as a hypoglycemic agent by subjects with T2DM.…”

Section: Impact Of Phytochemicals On Blood Glucose Regulationmentioning

confidence: 99%

Impact of Diet Composition on Blood Glucose Regulation

Russell

Baka

Björck

et al. 2013

Critical Reviews in Food Science and Nutrition

191

121

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Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary components on blood glucose levels. Included are the major macronutrients; carbohydrate, protein and fat, micronutrient vitamins and minerals, nonnutrient phytochemicals and additional foods including low-calorie sweeteners, vinegar, and alcohol. Based on the evidence presented in this review, it is clear that dietary components have significant and clinically relevant effects on blood glucose modulation. An integrated approach that includes reducing excess body weight, increased physical activity along with a dietary regime to regulate blood glucose levels will not only be advantages in T2DM management, but will benefit the health of the population and limit the increasing worldwide incidence of T2DM.

show abstract

Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Cited by 28 publications

References 37 publications

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Regulation of signaling molecules associated with insulin action, insulin secretion and pancreatic β-cell mass in the hypoglycemic effects of Korean red ginseng in Goto-Kakizaki rats

Impact of Diet Composition on Blood Glucose Regulation

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