Korean traditional Chungkookjang improves body composition, lipid profiles and atherogenic indices in overweight/obese subjects: a double-blind, randomized, crossover, placebo-controlled clinical trial

Ms, Byun; Ok, Yu Jung; Ys, Cha; Ts, Park

doi:10.1038/ejcn.2016.77

Cited by 42 publications

(39 citation statements)

References 41 publications

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“…In the present research, however, the nuclear magnetic resonance revealed the absence of discrepancies in body composition after FFP supplementation. It differs from previous results on fermented food in controlled intervention studies [18,97] and animals models [98] which evidenced a significant decrease in body weight and fat depots. Nevertheless, the absence of significant changes in body composition did not abstain from improvements in glucose homeostasis, what matches well with previous findings in murine models of obesity [99,100].…”

Section: Discussioncontrasting

confidence: 99%

A Fermented Food Product Containing Lactic Acid Bacteria Protects ZDF Rats from the Development of Type 2 Diabetes

et al. 2019

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Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received increasing attention in T2D etiology and progression. In the present study, we have explored the effect of long-term supplementation with a non-dairy fermented food product (FFP) in Zucker Diabetic and Fatty (ZDF) rats T2D model. The supplementation with FFP induced an improvement in glucose homeostasis according to the results obtained from fasting blood glucose levels, glucose tolerance test, and pancreatic function. Importantly, a significantly reduced intestinal glucose absorption was found in the FFP-treated rats. Supplemented animals also showed a greater survival suggesting a better health status as a result of the FFP intake. Some dissimilarities have been observed in the gut microbiota population between control and FFP-treated rats, and interestingly a tendency for better cardiometabolic markers values was appreciated in this group. However, no significant differences were observed in body weight, body composition, or food intake between groups. These findings suggest that FFP induced gut microbiota modifications in ZDF rats that improved glucose metabolism and protected from T2D development.

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Section: Discussioncontrasting

confidence: 99%

A Fermented Food Product Containing Lactic Acid Bacteria Protects ZDF Rats from the Development of Type 2 Diabetes

et al. 2019

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“…The chungkookjang has also alleviated diabetic symptoms in partial pancreatectomized rats, a type 2 diabetic animal model [ 7 , 10 ] and it has also reduced memory deficit in amyloid-β infused rats, an AD animal model [ 6 ]. Furthermore, 12-week treatment of chungkookjang extract has reported to reduce body fat and waist circumferences and increase lean body mass in overweight/obese women and it has improved lipid profiles in all obese subjects in a double-blinded, randomized, crossover, placebo-controlled clinical trial [ 26 ]. Thus, the results of in vitro studies can be applied to animal and human studies.…”

Section: Discussionmentioning

confidence: 99%

Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells

Jeong¹,

Jeong²,

Kim

et al. 2018

Nutrients

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We hypothesized that soybeans fermented with Bacillus spp. for 48 h (chungkookjang) would be rich in poly-γ-glutamate (γ-PGA) and would have greater efficacy for improving insulin sensitivity and insulin secretion in 3T3-L1 adipocytes, min6 cells, and PC12 neuronal cells. We screened 20 different strains of B. subtillus and B. amyloliquefaciens spp. for γ-polyglutamate (PGA) production and their anti-diabetic and anti-dementia activities in cell-based studies. Chungkookjang made with two B. amyloliquefaciens spp. (BA730 and BA731) were selected to increase the isoflavonoid and γ-PGA. Insulin-stimulated glucose uptake was higher in 3T3-L1 adipocytes given both chungkookjang extracts than in the cells given vehicle (control). The ethanol extract of BA731 (BA731-E) increased the uptake the most. Triglyceride accumulation decreased in BA731-E and BA731-W and the accumulation increased in BA730-W and BA730-E. The mRNA expression of fatty acid synthetase and acetyl CoA carboxylase was much lower in BA731-E and BA731-W and it was higher in BA730-W than the control. BA730-E and BA730-W also increased peroxisome proliferator-activated receptor (PPAR)-γ activity. Glucose-stimulated insulin secretion increased with the high dosage of BA730-W and BA730-E in insulinoma cells, compared to the control. Insulin contents and cell survival in high glucose media were higher in cells with both BA731-E and BA730-E. Triglyceride deposition and TNF-α mRNA expression were lower in BA731 than the control. The high-dosage treatment of BA730-E and BA731-E increased differentiated neuronal cell survival after treating amyloid-β(25-35) compared to the control. Brain-derived neurotrophic factor and ciliary neurotrophic factor, indices of neuronal cell proliferation, were higher in BA730 and BA731 than in the control. Tau expression was also reduced in BA731 more than the control and it was a similar level of the normal-control. In conclusion, BA730 increased PPAR-γ activity and BA731 enhanced insulin sensitivity in the brain and periphery. BA730 and BA731 prevented and alleviated the symptoms of type 2 diabetes and Alzheimer’s disease with different pathways.

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“…At the end of the intervention, it was found that soy isoflavone supplementation significantly reduced metabolic parameters and systolic BP ( P < 0.01), thereby significantly improving cardiovascular risk markers and calculated cardiovascular risk during early menopause compared to soy protein without isoflavones (103). Byun et al (105) described the effect of Chungkookjang supplementation, a Korean fermented soybean food with approximately 50 mg/g of isoflavones, on body composition, dyslipemia, and risk factors for atherosclerosis in overweight/obese subjects. After the intervention, apolipoprotein A1 (Apo A1) was significantly increased in the male Chungkookjang group ( P < 0.05) alone.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Apo A1 was also significantly increased in both the placebo and the Chungkookjang group, whereas apolipoprotein B (Apo B) was significantly decreased in the Chungkookjang group ( P < 0.05). In addition, in the Chungkookjang group, hs-CRP showed a tendency to decreasing and significantly differed between the two groups ( P < 0.05) (105). These results suggest that supplementation with Chungkookjang may improve body composition and risk factors for CVD in overweight and obese adults.…”

Section: Flavonoidsmentioning

confidence: 99%

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

et al. 2019

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Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.

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Korean traditional Chungkookjang improves body composition, lipid profiles and atherogenic indices in overweight/obese subjects: a double-blind, randomized, crossover, placebo-controlled clinical trial

Abstract: In conclusion, these results suggest that supplementation with Chungkookjang may improve body composition and risk factors for cardiovascular disease in overweight and obese adults.

Cited by 42 publications

References 41 publications

A Fermented Food Product Containing Lactic Acid Bacteria Protects ZDF Rats from the Development of Type 2 Diabetes

A Fermented Food Product Containing Lactic Acid Bacteria Protects ZDF Rats from the Development of Type 2 Diabetes

Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

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