The aim of this study is to evaluate the individual entrepreneurship perceptions and hopelessness levels of university students studying in the field of health sciences, to determine the affecting sociodemographic factors and to reveal the effect of hopelessness level on individual entrepreneurship perception. The population of the study consists of undergraduate students studying in the faculty of health sciences of a university in Turkey. The data were obtained with sociodemographic information form, Individual Entrepreneurship Perception Scale and Beck Hopelessness Scale and the survey method was used with face-to-face interviews. The results obtained from this study completed with the participation of 681 students showed that the individual entrepreneurship perception levels of the students studying in the field of health sciences were high (117,95±16,84; min: 44-max: 155) and their hopelessness levels were moderate (9,06±5,36; min: 0-max: 20). The results of the correlation analysis revealed that students' perceptions of individual entrepreneurship were negatively and moderately (r=- 0,498) related to their hopelessness levels. The results of the regression analysis showed that students' hopelessness levels and its sub-dimensions explained 26.3% of the total variance on individual entrepreneurship perception, and the increase in the participants' hopelessness perceptions regarding the sub-dimensions of hope (t=-7,383; p<0,001), loss of motivation (t=-2,470; p=0,014) and expectations for the future (t=-2,252; p<0,025) statistically decreased their individual entrepreneurship perceptions.Entrepreneurship education is necessary not only to shape the mindset of young people, but also to provide new skills, ideas and knowledge that are at the center of developing an entrepreneurial culture.