Abstract:A metal- and base-free, robust, and convenient approach for the synthesis of isoxazoline derivatives is reported. This protocol involves 1,3-dipolar cycloaddition between in situ generated nitrile oxides from the corresponding aldoximes using [hydroxy(tosyloxy)iodo]benzene (HTIB, Koser’s reagent) and maleimides, styrene and acrylonitrile. The described methodology is very attractive as it is operationally simple, has broad scope, and does not require any base, metal, or other additives.
A highly efficient, catalyst-free, metal-free, atom economic green protocol for the synthesis of arylthio/ arylamino methylene compounds by Michael attack of arylthiols and anilines on nitroolefins-derived from acenaphthaquinone and isatin...
A highly efficient, catalyst-free, metal-free, atom economic green protocol for the synthesis of arylthio/ arylamino methylene compounds by Michael attack of arylthiols and anilines on nitroolefins-derived from acenaphthaquinone and isatin...
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