IntroductionHaemophilia nursing practice has experienced a shift in the past decade, as the historic chief focus on factor infusions shifted to extended half‐life products, bispecific antibody therapies and other non‐replacement therapies. This evolution has driven a need for changes in nursing practice in many haemophilia treatment centres.AimThis article intends to provide insights to the haemophilia nurse to champion practice changes at their haemophilia treatment centres.MethodsTwo popular change theories, Lewin's three‐step change model and Kotter's eight‐step change model are discussed as a framework for haemophilia nurses to think, structure and be leaders in change.ConclusionExamples of these models in practice could give guidance and examples to reflect on for haemophilia nurses needing to make changes in their practice settings. These models of change, alongside existing haemophilia nurse competencies and tools such as the shared decision‐making tool from the World Federation of Hemophilia, can assist the nurse to be a capable change agent to usher in these new innovations.