Koyunlarda Tekrarlanan Sedasyonlarda Kullanılan Xylazinin Biyokimyasal ve Klinik Değerlere Etkisi

Abstract

The objective of the study is to determine the sedative effects of xylazine HCl administered to sheep in repeated fixed doses clinically and biochemically. Five Akkaraman breed rams identified to be clinically healthy were used in the study. Xylazine HCl was administered 4 times at a dose of 0.4 mg/kg intramuscular (fixed dose) with 4 day intervals to induce sedation. Rectal temperature, heart rate and respiratory rate along with rumen motility of all animals were evaluated before and after the administration. The depths of sedation and analgesia, control of reflexes along with various biochemical parameters were studied. The results showed that xylazine HCl led to change of less physiological parameters in the following administration in comparison with the first application. Whereas only moderate and deep sedation were observed in the first application on sheep; mild, moderate and deep sedation were observed in all remaining administration. The degree of analgesic effect was 0 during mild and moderate sedation periods whereas it was 1-2 during deep sedation period. It was concluded that repeated sedations of xylazine HCl administration reduce the degree of sedation in third and fourth administration in sheep. Keywords: Sheep, Xylazine HCl, Repeated sedation Koyunlarda Tekrarlanan Sedasyonlarda Kullanılan Xylazinin Biyokimyasal ve Klinik Değerlere Etkisi ÖzetBu çalışmada ksilazinin tekrarlayan dozlarda klinik ve biyokimyasal açıdan sedatif etkilerini araştırmak amaçlanmıştır. Çalışmada klinik olarak sağlıklı olduğu belirlenen 5 adet yetişkin Akkaraman ırkı koç kullanıldı. Sedasyon oluşturmak amacıyla her uygulamada xylazin HCl 0.4 mg/kg dozunda kas içi olarak (sabit doz) 4 gün arayla 4 uygulama yapıldı. Uygulama öncesi ve uygulama sonrası rektal vücut sıcaklığı, nabız ve solunum sayısı, rumen hareketleri, takip edildi. Ayrıca sedasyon ve analjezinin derinliği, reflekslerin kontrolü ile biyokimyasal bazı parametreler araştırıldı. İlk uygulamaya göre tekrarlayan dozlarda ksilazin HCl fizyolojik parametrelerde daha az değişikliğe neden oldu. İlk ugulamada sadece orta ve ileri derecede sedasyon şekillenirken, sonraki uygulamalarda hafif, orta ve ileri derecede sedasyon şekillendi. Hafif ve orta derece sedasyonda analjezinin derecesi 0 iken, derin sedasyonda 1-2 olarak saptandı. Sonuç olarak koyunlarda tekrarlayan sedasyonlarda verilen ksilazin HCI'nin üçüncü ve dördüncü uygulamalarında sedasyonun derecesini azalttığı sonucuna varıldı.

Analgesia for Sheep in Commercial Production: Where to Next?

“…The α-agonists are commonly used as sedative agents in livestock, but analgesic effects have also been demonstrated, particularly at below-sedative doses. At sedative doses (0.4 mg/kg xylazine in sheep), some of the findings must be interpreted with care: if a reduction in nociceptive response is recorded coincidental with moderate to deep sedation, but not when no or mild sedation is observed [325,374], is this truly evidence of analgesia, or merely evidence that the animal is unable to, or is very slow to, respond to the stimulus? However, at very low doses, reductions in nociceptive threshold (pinprick or electrical stimulus) have been reported [37,227,228,[375][376][377][378][379] when xylazine (0.05 mg/kg), clonidine (0.002-0.005 mg/kg) or detomidine (0.01 mg/kg) have been administered intravenously, intramuscularly, intraperitoneally or epidurally.…”