KRAS Addiction Promotes Cancer Cell Adaptation in Harsh Microenvironment Through Macropinocytosis

Seguin, Laetitia

doi:10.1007/978-3-030-94004-1_10

Cited by 1 publication

(2 citation statements)

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“…99 After PI3K activation, mTOR is subsequently activated in cells. 100 In particular, KRAS can directly bind to PIK3CA to activate the PI3K pathway, which causes the activation of mTOR. In addition, the loss of function of tumor suppressor proteins such as PTEN, p53, and TSC1/TSC2 will lead to the activation of mTOR in the pathological state of tumors.…”

Section: ■ Polysaccharides and Cancersmentioning

confidence: 99%

“…PIK3CA mutations induce sustained activation of the mTOR/PI3K/AKT pathway, which reduces cell dependence on growth factors and stimulates cell growth and conversion . After PI3K activation, mTOR is subsequently activated in cells . In particular, KRAS can directly bind to PIK3CA to activate the PI3K pathway, which causes the activation of mTOR.…”

Section: Mtor and Cancersmentioning

confidence: 99%

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Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

Guo

et al. 2022

J. Agric. Food Chem.

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Cancer is the most serious problem for public health. Traditional treatments often come with unavoidable side effects. Therefore, the therapeutic effects of natural products with wide sources and low toxicity are attracting more and more attention. Polysaccharides have been shown to have cancer-fighting potential, but the molecular mechanisms remain unclear. The mammalian target of rapamycin (mTOR) pathway has become an attractive target of antitumor therapy research in recent years. The regulation of mTOR pathway not only affects cell proliferation and growth but also has an important effect in tumor metabolism. Recent studies indicate that dietary polysaccharides play a vital role in cancer prevention and treatment by regulating mTOR pathway. Here, the progress in targeting mTOR signaling by dietary polysaccharides in cancer prevention and their molecular mechanisms are systemically summarized. It will promote the understanding of the anticancer effects of polysaccharides and provide reference to investigators of this cutting edge field.

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Section: ■ Polysaccharides and Cancersmentioning

confidence: 99%

Section: Mtor and Cancersmentioning

confidence: 99%