Kribbella solani sp. nov. and Kribbella jejuensis sp. nov., isolated from potato tuber and soil in Jeju, Korea

Song, Jaekyeong; Kim, Byung-Yong; Hong, Seung‐Beom; Cho, Hyun-Suk; Sohn, Kyoung-Hee; Chun, Jongsik; Suh, Joo‐Won

doi:10.1099/ijs.0.02953-0

Cited by 33 publications

(5 citation statements)

References 18 publications

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“…The gene sequence showed high similarity with those of the genus Kribbella, such as Kribbella aluminosa (JCM 14599 T , 1419/1432 bp, T: Type strain, 99.1%) 11 and K. solani (JCM 12205 T , 1433/1453 bp, 98.6%). 12 These phenotypic and genotypic data suggested that strain MI481-42F6 belongs to the genus Kribbella. Therefore, the strain was tentatively designated as Kribbella sp.…”

Section: Resultsmentioning

confidence: 97%

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6

et al. 2017

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Yeast capping enzymes differ greatly from those of mammalian, both structurally and mechanistically. Yeast-type capping enzyme repressors are therefore candidate antifungal drugs. The 5ʹ-guanine-N7 cap structure of mRNAs are an essential feature of all eukaryotic organisms examined to date and is the first co-transcriptional modification of cellular pre-messenger RNA. Inhibitors of the RNA 5ʹ-triphosphatase in yeast are likely to show fungicidal effects against pathogenic yeast such as Candida. We discovered a new RNA 5ʹ-triphosphatase inhibitor, designated as the kribellosides, by screening metabolites from actinomycetes. Kribellosides belong to the alkyl glyceryl ethers. These novel compounds inhibit the activity of Cet1p (RNA 5ʹ-triphosphatase) from Saccharomyces cerevisiae in vitro with IC 50 s of 5-8 μM and show antifungal activity with MICs ranging from 3.12 to 100 μg ml À1 against S. cerevisiae.

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Section: Resultsmentioning

confidence: 97%

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6

et al. 2017

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“…Although the chemical potential of the genus has not been evaluated extensively to date, some species have shown a high potential for producing the following new bioactive agents: Kribbella koreensis, which produces neuropilin/growth factor complexes [ 19 ], Kribbella antibiotica, which shows antifungal activity [ 20 ], Kribbella jejuensis that inhibits the growth of Streptomyces scabiei [ 21 ], and Kribbella sp. UTMC 267 has been proven to possess anti-calcification properties [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens

et al. 2022

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Current needs in finding new antibiotics against emerging multidrug-resistant superbugs are pushing the scientific community into coming back to Nature for the discovery of novel active structures. Recently, a survey of halophilic actinomyectes from saline substrates of El Saladar del Margen, in the Cúllar-Baza depression (Granada, Spain), led us to the isolation and identification of 108 strains from the rhizosphere of the endemic plant Limonium majus. Evaluation of the potential of these strains to produce new anti-infective agents against superbug pathogens was performed through fermentation in 10 different culture media using an OSMAC approach and assessment of the antibacterial and antifungal properties of their acetone extracts. The study allowed the isolation of two novel antibiotic compounds, kribbellichelin A (1) and B (2), along with the known metabolites sandramycin (3), coproporphyrin III (4), and kribelloside C (5) from a bioassay-guided fractionation of scaled-up active extracts of the Kribbella sp. CA-293567 strain. The structures of the new molecules were elucidated by ESI-qTOF-MS/MS, 1D and 2D NMR, and Marfey’s analysis for the determination of the absolute configuration of their amino acid residues. Compounds 1–3 and 5 were assayed against a panel of relevant antibiotic-resistant pathogenic strains and evaluated for cytotoxicity versus the human hepatoma cell line HepG2 (ATCC HB-8065). Kribbellichelins A (1) and B (2) showed antimicrobial activity versus Candida albicans ATCC-64124, weak potency against Acinetobacter baumannii MB-5973 and Pseudomonas aeruginosa MB-5919, and an atypical dose-dependent concentration profile against Aspergillus fumigatus ATCC-46645. Sandramycin (3) confirmed previously reported excellent growth inhibition activity against MRSA MB-5393 but also presented clear antifungal activity against C. albicans ATCC-64124 and A. fumigatus ATCC-46645 associated with lower cytotoxicity observed in HepG2, whereas Kribelloside C (5) displayed high antifungal activity only against A. fumigatus ATCC-46645. Herein, we describe the processes followed for the isolation, structure elucidation, and potency evaluation of these two new active compounds against a panel of human pathogens as well as, for the first time, the characterization of the antifungal activities of sandramycin (3).

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“…The potential for hydrolytic activity, particularly beta-glucosidase activity, was also shown for bacteria belonging to the genera Microlunatus [60] and Kribbella. In particular, K. jejuensis was mentioned for its utilisation of xylan and cellobiose [61].…”

Section: Plos Onementioning

confidence: 99%

The difference between cellulolytic ‘culturomes’ and microbiomes inhabiting two contrasting soil types

et al. 2020

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High-throughput 16S rRNA sequencing was performed to compare the microbiomes inhabiting two contrasting soil types—sod-podzolic soil and chernozem—and the corresponding culturome communities of potentially cellulolytic bacteria cultured on standard Hutchinson media. For each soil type, soil-specific microorganisms have been identified: for sod-podzolic soil—Acidothermus, Devosia, Phenylobacterium and Tumebacillus, and for chernozem soil—Sphingomonas, Bacillus and Blastococcus. The dynamics of differences between soil types for bulk soil samples and culturomes varied depending on the taxonomic level of the corresponding phylotypes. At high taxonomic levels, the number of common taxa between soil types increased more slowly for bulk soil than for culturome. Differences between soil-specific phylotypes were detected in bulk soil at a low taxonomic level (genus, species). A total of 13 phylotypes were represented both in soil and in culturome. No relationship was shown between the abundance of these phylotypes in soil and culturome.

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Kribbella solani sp. nov. and Kribbella jejuensis sp. nov., isolated from potato tuber and soil in Jeju, Korea

Cited by 33 publications

References 18 publications

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6

Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens

The difference between cellulolytic ‘culturomes’ and microbiomes inhabiting two contrasting soil types

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