Krill Oil Combined with Bifidobacterium animalis subsp. lactis F1-7 Alleviates the Atherosclerosis of ApoE−/− Mice

Liu, Xi; Zhang, Zhe; Lv, Yan; Lü, Haiyan; Liu, Tongjie; Yi, Huaxi; Zhao, Maozhen; Zhang, Lanwei; Gong, Pimin

doi:10.3390/foods10102374

Cited by 9 publications

(5 citation statements)

References 45 publications

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“…Akkermansia and Bifidobacterium are conductive to the reduction of LPS leakage via protecting the gut mucosal barrier function [48,49]. Bifidobacterium plays a synergistic effect in the improvement of inflammation to further alleviated the atherosclerosis [50]. Akkermansia is implicated in declining aortic lesions and atherosclerosis [51].…”

Section: Plos Onementioning

confidence: 99%

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice

Yang

Liu

et al. 2023

PLoS ONE

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Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated to play a crucial role in the occurrence and development of AS inflammation. Butyrate, a bioactive molecule produced by the intestinal flora, has been increasingly demonstrated to exhibit a vital role for regulating the inflammation in chronic metabolic diseases. However, the effectiveness and multiple anti-inflammation mechanisms of butyrate on AS still need to be further understood. ApoE−/− mice fed with high-fat diet as AS model were administered with sodium butyrate (NaB) for 14 weeks of treatment. Our results showed that the atherosclerotic lesion in the AS group was dramatically reduced after NaB intervention. Moreover, deteriorated routine parameters of AS including body weights (BWs), low-density lipoprotein (LDL-C), triglyceride (TG), total cholesterol (TC) were significantly reversed by NaB administration. Abnormal elevated plasma and aorta pro-inflammatory indicators including interleukin (IL)-1β, IL-6, IL-17A, tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS), as well as reduced anti-inflammatory IL-10 in plasma were respectively rectified after NaB administration. Consistently, accumulated Mψ and associated imbalance of polarization in the arota were attenuated with NaB treatment. Importantly, we demonstrated that the suppression of Mψ and associated polarization of NaB was dependent on binding G-protein coupled receptor (GPR) and inhibiting histone deacetylase HDAC3. Moreover, we found that intestinal butyrate-producing bacteria, anti-inflammatory bacteria and intestinal tight junction protein zonula occludens-1 (ZO)-1 may contribute to this effectiveness. Intriguingly, according to transcriptome sequencing of atherosclerotic aorta, 29 elevated and 24 reduced miRNAs were found after NaB treatment, especially miR-7a-5p, suggesting that non-coding RNA may possess a potential role in the protection of NaB against AS. Correlation analysis showed that there were close complicated interactions among gut microbiota, inflammation and differential miRNAs. Collectively, this study revealed that dietary NaB may ameliorate atherosclerotic inflammation by regulating Mψ polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice.

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Section: Plos Onementioning

confidence: 99%

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice

Yang

Liu

et al. 2023

PLoS ONE

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“…Furthermore, krill oil increased TC and bile acid levels in the feces of experimental rats, and promoted bile acid metabolism and cholesterol efflux [59]. Liang et al [60] found that a combination intervention using krill oil and Bifidobacterium animalis subsp. Lactobacillus F1-7 significantly reduced the atherosclerotic plaque area, anti-inflammatory factor levels and modulated the cholesterol 7-alpha hydroxylase (CYP7A1) pathway to reduce lipid accumulation in mice.…”

Section: Marine-derived Unsaturated Fatty Acidsmentioning

confidence: 99%

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

Liu,

Chen,

Chen

et al. 2023

Nutrients

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Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.

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“…It can be used as a potential target for the treatment of CHD to regulate lipid metabolism and reduce inflammation [18] . BA plays an important role in intestinal microbiota and cholesterol excretion [19] , it mainly binds to FXR and TGR5 [20] , inhibition of FXR can promote BAs metabolism [21] , improve atherosclerosis and slow down the development of CHD; activation of TGR5 can reduce the area of atherosclerotic plaque and inflammation in plaque, and inhibit macrophage phagocytosis of oxLDL [22] . TMAO can promote thrombosis and vascular endothelial injury and promote the production of atherosclerotic plaques [23] , thereby increasing the risk of CHD.…”

Section: Intestinal Flora and The Mechanism Of Occurrence And Develop...mentioning

confidence: 99%

The Relationship between Intestinal Microflora and Coronary Heart Disease and the Research Status of Traditional Chinese Medicine Intervention

2023

IJFM

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Coronary heart disease (CHD) is a disease such as angina pectoris caused by lumen stenosis caused by coronary atherosclerosis. It is one of the cardiovascular diseases with high morbidity and mortality. The pathogenesis of the disease is very complex, and there are many inducing factors. Modern studies have shown that intestinal flora is a new target for the prevention and treatment of CHD. Inflammation caused by intestinal flora imbalance and its metabolites such as short-chain fatty acids (SCFAs), bile acids (BAs) and trimethylamine oxide (TMAO) can directly or indirectly affect the development of CHD. In recent years, Chinese medicine intervention on intestinal flora in the prevention and treatment of CHD has been a hot topic. Modern doctors have made many achievements in the use of traditional Chinese medicine to intervene intestinal flora in the prevention and treatment of CHD based on the theory of "heart-to-small intestine", the theory of homology of medicine and food, and the theory of acupuncture and moxibustion. This paper summarizes the research on the intervention of traditional Chinese medicine on intestinal flora in the prevention and treatment of CHD by consulting relevant contributions in Chinese andEnglish in recent years. It is found that monomers or extracts of traditional Chinese medicine, Chinese medicine pairs and traditional Chinese medicine preparations can regulate the occurrence and development of CHD by interfering with intestinal flora, such as regulating the risk factors of CHD, such as blood glucose and blood lipids, or increasing the production of SCFAs to prevent atherosclerosis, reducing the production of TMAO and preventing thrombosis. It is expected that this discussion can provide a new idea for traditional Chinese medicine to interfere with intestinal flora in the prevention and treatment of CHD.

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Krill Oil Combined with Bifidobacterium animalis subsp. lactis F1-7 Alleviates the Atherosclerosis of ApoE−/− Mice

Cited by 9 publications

References 45 publications

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

The Relationship between Intestinal Microflora and Coronary Heart Disease and the Research Status of Traditional Chinese Medicine Intervention

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