Kronik Böbrek Yetmezliğinde Göz Kırpma Refleksi Değişiklikleri

Abstract

Arafl t›r ma Ma ka le si / Re se arch Ar tic le 102 Ya z›fl m a Ad re si/Ad dress for C or res pon den ce: Dr. Hasan Hüseyin Kozak, Beyhekim Devlet Hastanesi, Nöroloji Bölümü, Konya, Türkiye Gsm: +90 533 360 05 54 E-pos ta: hhkozak@gmail.com G e liş ta ri hi/Re cei ved: 16.01.2011 K a bul ta ri hi/ Ac cep ted: 17.08.2011 © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. / © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing. ABS TRACTO b jec ti ve: The purpose of this study was to investigate the effects of hemodialysis and peritoneal dialysis on the peripheral and central nervous system in patients with uremia associated with chronic renal failure.Met hod: In this study, 35 hemodialysis and 35 peritoneal dialysis patients were compared with 70 healthy controls by working in blink reflex after assessment of peripheral neuropathy by neurological examination and performing EMG.Re sults: Ipsilateral R2 (R2i) and contralateral R2 (R2c) response latencies were found to be significantly prolonged in patients with chronic renal failure compared to those of controls. Also, latencies of R2 responses in hemodialysis patients, in whom polyneuropathy was detected, were significantly longer than those of the peritoneal dialysis patients, while latencies of R1 responses were unaffected. C o n c lu si o n : For extraaxial lesions, R2 is less sensitive than R1, but in intraaxial lesions abnormality of R2 is as frequent as short latency responses, the R2 being more complex and spreads to the caudal medulla. Hence, in chronic renal failure patients sparing of the R1 and prolongation of the R2 indicates a subclinical intraaxial involvement. There was no significant difference in R1, R2i and R2c values between peritonal dialysis patients with polyneuropathy and controls. R1 values in hemodialysis patients with polyneuropathy were found to be within normal range while R2i and R2c values were significantly prolonged when compared to controls; suggesting that intraaxial subclinical involvement is more frequently seen in hemodialysis patients. (Arc hi ves of Neu ropsy chi atry 2012; 49: 102-107)