Kronik karaciğer hastalığı olan çocukluklarda doğal antikoagülan düzeyleri

Abstract

K Kr ro on ni ik k k ka ar ra ac ci i¤ ¤e er r h ha as st ta al l› ›¤ ¤› › o ol la an n ç ço oc cu uk kl lu uk kl la ar rd da a d do o¤ ¤a al l a an nt ti ik ko oa ag gü ül la an n d dü üz ze ey yl le er ri i N Na at tu ur ra al l a an nt ti ic co oa ag gu ul la an nt t l le ev ve el ls s i in n c ch hi il ld dr re en n w wi it th h c ch hr ro on ni ic c l li iv ve er r d di is se ea as se e E E. . M Ma ah hi ir r G Gü ül lc ca an n, , T Tu uf fa an n K Ku ut tl lu u* *, , T Tü ül la ay y E Er rk ka an n* *, , F Fü üg ge en n Ç Çu ul ll lu u Ç Ço ok ku u¤ ¤r ra afl fl* * S Su um mm ma ar ry yAim: The aim of this study was to evaluate the serum levels of natural anticoagulants and their possible role as a marker in determining the severity of liver disease. Material and Method: Protein C, protein S and antithrombin levels were measured in 44 children with hepatit B-related chronic liver disease (26 chronic hepatitis, 18 cirrhosis) and in 20 healty controls using an automated functional clotting assay, automated functional assay and chromogenic assay, respectively. Results: In comparison with chronic hepatitis patients, cirrhotics had significantly decreased protein C levels. There was no significant difference in protein S and antitrombin levels between these two groups. All anticoagulants were significantly reduced in chronic liver patients in comparison to the control group. Conclusions: In children with chronic liver disease, reduction of natural anticoagulants is common, and protein C levels may used as a marker of hepatocellular damage. (Turk Arch Ped 2010; 45: 238-41)