Krukenberg tumor in pregnancy: a rare case and review of the literature

Goidescu, Iulian; Nemeti, Georgiana; Preda, Andreia; Kovacs, Tunde; Surcel, Mihai; Eniu, Dan; Cruciat, Gheorghe; Mureşan, Daniel

doi:10.1080/14767058.2021.1946788

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…Their preferential occurrence in young women is due to hypervascularity of ovaries and hormonal effects during the childbearing age. In fact, the development of Krukenberg tumor during pregnancy has been reported by several authors 12,13 …”

Section: Discussionmentioning

confidence: 85%

“…In fact, the development of Krukenberg tumor during pregnancy has been reported by several authors. 12,13 The exact mechanisms for the spread of gastrointestinal cancers to the ovaries have not been fully elucidated. It is postulated that lymphangitic pathways are primarily involved in the development of Krukenberg tumors from gastric cancer, whereas the transperitoneal seeding or hematogenous metastases occur in patients with colon carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Krukenberg Tumors in Young Women: Computed Tomography and Magnetic Resonance Imaging Diagnosis

Ghahremani

2023

J Comput Assist Tomogr

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Introduction The purpose of this report was to present the computed tomography (CT) and magnetic resonance imaging (MRI) features of Krukenberg tumors and to review the pertinent clinical data about the rising incidence of this malignancy among young women. Material and Methods This series included 8 women who ranged in age from 24 to 44 years (mean, 36.3 years). They were diagnosed to have Krukenberg tumors during a 5-year period (2011–2016). All patients were evaluated by abdominal CT and pelvic or transvaginal sonography. Five of them also had MRI of the abdomen, and 3 had positron emission tomography scans. Results The primary cancer was located in the stomach of 7 patients and in the colon in 1. The initial presentation was due to large pelvic mass and abdominal distention by ascites in 3 patients, gastrointestinal symptoms in 4, and small bowel obstruction by carcinoma of the ascending colon in 1 woman. Ovarian metastases were demonstrated on the initial imaging examination of 5 patients and developed as metachronous lesion during follow-up in 3 cases. Six women died 3 to 23 months (mean, 11 months) after the diagnosis. One has survived for 6 years after extensive surgery, and 1 was lost to follow-up. Conclusions Krukenberg tumors are being diagnosed with an increasing frequency because of well-documented rising incidence of gastric and colorectal carcinomas among young women. Therefore, those presenting with gastrointestinal cancer should have careful imaging of their ovaries for possible metastases, and conversely, the clinical or sonographic detection of bilateral ovarian masses would require evaluation by CT or MRI of the abdomen in search for a potential primary gastrointestinal cancer. This report highlights the CT and MRI features of this neoplastic process and reviews the current concepts about its development and management.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Krukenberg Tumors in Young Women: Computed Tomography and Magnetic Resonance Imaging Diagnosis

Ghahremani

2023

J Comput Assist Tomogr

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“…From Goidescu et al the mean age of women complicated with a Krukenberg tumor during pregnancy was 30.4 years, and the most common primary cancer origin was the stomach (68.6%) followed by the colon (14.3%) 7 . The most common symptoms of a Krukenberg tumor are general gastric-intestinal discomfort, including abdominal pain, nausea, and vomiting all of which are similar to pregnancy-related discomfort.…”

Section: Discussionmentioning

confidence: 97%

The challenging presentation of gastric cancer during pregnancy with krukenberg tumor: a case report

Chen¹,

Lee²,

Lin³

2023

Annals of Medicine &Amp; Surgery

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Introduction: The incidence of ovarian tumors in pregnancy is around 0.05%. Primary ovarian cancer and metastatic malignancy are rare in pregnancy, and women often delayed in diagnosis. Importance: This is the first case ever reported on gastric cancer diagnosed during pregnancy presenting with a Krukenberg tumor and mimic ovarian tumor torsion, cholecystitis. By reporting this case, we could sensitize physicians to be more vigilance of abnormal abdominal pain in pregnant women. Case presentation: A 30-year-old female came to our hospital at the 30th week of gestational age due to preterm uterine contraction and worsening abdominal pain. A cesarean section was performed due to preterm uterine contraction and intolerable abdominal pain suspected to be ovarian torsion. Microscopic examination of the ovarian specimen showed signet-ring cells. The patient was diagnosed with gastric adenocarcinoma at stage IV after complete surveillance. Postpartum chemotherapy consisted of oxaliplatin and high-dose 5-fluorouracil. The patient died 4 months after delivery. Clinical discussion: Malignancies during pregnancy should be kept in mind while encountering atypical clinical presentations. Krukenburg tumor is rare in pregnancy and gastric cancer is the most common cause. Early diagnosis of the gastric cancer in the operable stage is the key to a better prognosis. Conclusion: Diagnostic examinations for gastric cancer in pregnancy could be performed after first trimester. Treatment should be introduced after balancing maternal-fetal risks. Early diagnosis and intervention are crucial to decrease the high mortality rate of gastric cancer in pregnancy.

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“…The occurrence of KT during pregnancy is infrequent, and so far, only 44 cases have been reported in the literature. [12][13][14][15] SBM has been reported in 4% of patients with cancer. The common primary site includes the prostate, breast, and lung.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of KT during pregnancy is infrequent, and so far, only 44 cases have been reported in the literature. 12–15…”

Section: Discussionmentioning

confidence: 99%

Skull Base Metastasis and Krukenberg Tumor in a Pregnant Woman: An Unusual Presentation of Metastatic Gastric Cancer

Chellan,

Senthamizhselvan,

Nair

et al. 2024

ACG Case Rep J

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Gastric cancer is an infrequent cause of vomiting during pregnancy. It is often diagnosed at an advanced stage due to late presentation by patients, mistaking it for gestational symptoms. We report a 24-year-old pregnant woman with gastric cancer with skull base metastasis and Krukenberg tumor on initial diagnosis. She underwent medical termination of pregnancy and best supportive care before dying of her illness.

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Krukenberg tumor in pregnancy: a rare case and review of the literature

Cited by 6 publications

References 29 publications

Krukenberg Tumors in Young Women: Computed Tomography and Magnetic Resonance Imaging Diagnosis

Krukenberg Tumors in Young Women: Computed Tomography and Magnetic Resonance Imaging Diagnosis

The challenging presentation of gastric cancer during pregnancy with krukenberg tumor: a case report

Skull Base Metastasis and Krukenberg Tumor in a Pregnant Woman: An Unusual Presentation of Metastatic Gastric Cancer

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