Krukenberg Tumor of the Testicle, Report of a Second Case

Hunter, Dewitt T.; Hutcheson, James B.

doi:10.1016/s0022-5347(17)66014-2

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…Of course all tumour metastatic to the testis must arrive via the spermatic cord, unless there is a congenital hydrocoele, but no tumour has yet been shown to metastasise along the vas and the apparent excess of prostatic secondaries which the theory seeks to explain may be accounted for by reporting bias: metastases are routinely sought in therapeutic orchidectomy specimens. Tumour emboli are, however, commonly seen within lymphatic and vascular channels in the vas [18], and we agree with Hunter and Hutcheson [41] that metastases reach the testes predominantly through the vascular system. Vascular spread also seems to be the route of metastases to the penis, although their rarity in so vascular an organ suggests that it is an unpermissive environment for tumour growth [30].…”

Section: Routes Of Metastasissupporting

confidence: 88%

The significance of secondary neoplasms of the urinary and male genital tract

Bates

Baithun

2001

Virchows Arch

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Secondary neoplasms account for some 1.6-3.0% of solid malignancies encountered in surgical specimens from the genitourinary tract. At autopsy the proportion is higher, largely due to sampling bias. The peak incidence occurs around the seventh decade, and male and female incidences are approximately equal at all sites except the kidney, which shows a male preponderance owing to an excess of metastatic lung cancer. Adenocarcinomas are the most common histological type of secondary neoplasm and may be histologically and immunohistochemically indistinguishable from primary neoplasms arising from colonic-type epithelial metaplasia. Seeding of tumour along the urinary passages does not appear to be a significant mechanism of metastasis, and spread from one part of the genitourinary tract to another is uncommon. Clinical information and ancillary investigations are more helpful than special histological techniques in differential diagnosis.

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Section: Routes Of Metastasissupporting

confidence: 88%

The significance of secondary neoplasms of the urinary and male genital tract

Bates

Baithun

2001

Virchows Arch

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“…Signet-ring cell carcinoma of the testis from the gastrointestinal tract (`Krukenberg' tumour of the testis) is a rare but histologically distinctive finding, though the tumour cells can be inconspicuous if the infiltrate is diffuse. 19,20 Although secondaries from retinoblastomas 4,21 and neuroblastomas 4,21,22 have been reported, this is the first reported case of medulloblastoma metastasizing to the testis. Some 5% Secondary testicular neoplasia 329 of medulloblastomas overall metastasize outside the neuraxis, 23 and seeding of malignant cells is usually, as in our case, secondary to surgical intervention.…”

Section: Discussionmentioning

confidence: 81%

“…Lung is the second most common primary site and all the pulmonary tumours in the present series were small cell carcinomas involving the right testis in a multifocal pattern in patients in their fifth and sixth decades. Signet‐ring cell carcinoma of the testis from the gastrointestinal tract (‘Krukenberg’ tumour of the testis) is a rare but histologically distinctive finding, though the tumour cells can be inconspicuous if the infiltrate is diffuse 19,20 . Although secondaries from retinoblastomas 4,21 and neuroblastomas 4 , 21,22 have been reported, this is the first reported case of medulloblastoma metastasizing to the testis.…”

Section: Discussionmentioning

confidence: 99%

Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children

2000

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“…Pathologically, testicular metastases may be in the form of a focal nodule5,9*'2,20,23*30,32 or diffuse involvement.5*'3,26. 31 The tumor often occupies the interstitium, with relative sparing of the seminiferous tu- The tubules are frequently compressed, ymphatic and with atrophy and hyalinizati~n.'. '~,'~,'~,~~,~~ L vascular invasion are often p r e~e n t .~~'~~~'~~~~ A desmoplastic reaction is rarely seen35; this was present in one of our patients (Case 1).…”

Section: Review Of the Literaturementioning

confidence: 99%

Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms

Haupt

Mann

Trump

et al. 1984

Cancer

132

102

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Metastatic carcinoma to the testis is unusual. There are only seven previously reported cases in which a testicular mass was the first clinical manifestation of an underlying malignancy. The authors review 127 cases in which the testis was involved by metastatic carcinoma, and describe an additional two patients in whom a malignant testicular mass was the presenting sign of an underlying nontesticular carcinoma. The tumors most commonly reported to metastasize to the testis are: prostate (45 cases), lung (25 cases), melanoma (12 cases), colon (11 cases), kidney (10 cases), stomach (6 cases), and pancreas (5 cases). Neuroblastoma, retinoblastoma, carcinoid tumor, and cancers of the bile duct, ureter, bladder, salivary gland, and thyroid have also involved the testis secondarily. Nineteen patients (15%) had bilateral testicular metastases. Patients with secondary testicular neoplasms were older in general than those with germ cell tumors (mean, 55 years; median, 57 years). Histologically, the presence of extensive lymphatic and vascular invasion and an interstitial pattern, in which the seminiferous tubules are spared, is suggestive of a metastasis. In four of the nine cases (44%) in which testicular enlargement was the first manifestation of an underlying carcinoma the correct pathologic diagnosis was initially missed. Serum alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) are occasionally elevated in patients with nontesticular primary tumors, but markedly elevated levels in young patients suggest a nonseminomatous germ cell tumor, as does positive immunoperoxidase staining for AFP and HCG.Cancer 54:709-714, 1984.ERM CELL TUMORS are the most common testicular G neoplasms'** and should be the primary diagnostic consideration in young patients who present with a solitary testicular mass. However, the testes may also be the site of metastatic di~ease.~-~' When an occult malignancy first becomes manifest as a testicular mass, its distinction from a primary testicular tumor may be difficult. We report two patients who presented with testicular metastases from clinically occult primary neoplasms; the clinical features of one patient have been previously reported. 44 We review the literature regarding testicular metastases and emphasize the clinical and pathologic differences between primary and secondary testicular neoplasms.

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Krukenberg Tumor of the Testicle, Report of a Second Case

Cited by 10 publications

References 4 publications

The significance of secondary neoplasms of the urinary and male genital tract

The significance of secondary neoplasms of the urinary and male genital tract

Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children

Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms

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