Krukenberg Tumor Secondary to Pancreatic Ductal Adenocarcinoma: A Case Report

Abstract

Introduction: A metastatic tumor of the ovary known as Krukenburg Tumor (KT) is a mucin-rich signet-ring adenocarcinoma that arises from a gastrointestinal site in most cases and from other sites in less proportion. We describe a rare case presenting a Krukenberg tumor secondary to pancreatic ductal adenocarcinoma. Case Presentation: A 51-year-old female, who started her current condition 6 months ago, with 15 kg of weight loss, accompanied by nausea, vomiting, early satiety, and constipation. Computerized tomography showed dependent mass involving the body and tail of the pancreas with solid and cystic components, highly suggestive of a primary tumor as well as peritoneal carcinomatosis and a left ovarian mass, tumor (Krukenberg) as a first possibility. A laparoscopy was performed. The final pathology report was a pancreatic ductal adenocarcinoma with metastases to the ovary from the left salpingectomy. Conclusion: Pancreatic cancer presenting as Krukenberg tumor of the ovary is rare and easily misdiagnosed as primary ovary carcinomas, which leads to missed surgical opportunities. Resection of ovarian metastases combined with chemotherapy treatment may increase the overall survival even in patients with advanced pancreatic ductal adenocarcinoma.